EP 2491004 A2 20120829 - MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES
Title (en)
MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES
Title (de)
MAKROZYKLISCHE HEMMER VON SERINPROTEASEENZYMEN
Title (fr)
INHIBITEURS MACROCYCLIQUES DES ENZYMES DE PROTÉASE DE SÉRINE
Publication
Application
Priority
- US 25443409 P 20091023
- US 2010053754 W 20101022
Abstract (en)
[origin: WO2011050276A1] The present invention relates to novel macrocyclic compounds and salts thereof that bind to and/or are inhibitors of serine protease enzymes and methods of using the compounds. The present invention also relates to intermediates of these compounds, pharmaceutical compositions containing these compounds and methods of using the same. These compounds are useful as therapeutics for treatment and prevention of a range of disease indications including hyperproliferative disorders, in particular those characterized by tumor metastasis, inflammatory disorders, skin and tissue disorders, cardiovascular disorders, respiratory disorders and viral infections.
IPC 8 full level
C07C 225/00 (2006.01)
CPC (source: EP US)
A61K 31/395 (2013.01 - EP US); A61P 1/00 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/02 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 17/12 (2017.12 - EP); A61P 17/14 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 31/16 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011050276 A1 20110428; CA 2778503 A1 20110428; CA 2778504 A1 20110428; EP 2491004 A2 20120829; EP 2491004 A4 20130703; EP 2491020 A1 20120829; EP 2491020 A4 20130424; JP 2013508409 A 20130307; JP 2013508410 A 20130307; US 2012270769 A1 20121025; US 2012270807 A1 20121025; WO 2011050270 A2 20110428; WO 2011050270 A3 20110804
DOCDB simple family (application)
US 2010053767 W 20101022; CA 2778503 A 20101022; CA 2778504 A 20101022; EP 10825746 A 20101022; EP 10825750 A 20101022; JP 2012535415 A 20101022; JP 2012535418 A 20101022; US 2010053754 W 20101022; US 201013503426 A 20101022; US 201013503437 A 20101022