Title (en)

IMMUNOCONJUGATES COMPRISING POXVIRUS-DERIVED PEPTIDES AND ANTIBODIES AGAINST ANTIGEN-PRESENTING CELLS FOR SUBUNIT-BASED POXVIRUS VACCINES

Title (de)

IMMUNKONJUGATE MIT AUS DEM POXVIRUS ABGELEITETEN PEPTIDEN UND ANTIKÖRPERN GEGEN ZELLEN MIT ANTIGENEN FÜR UNTEREINHEITSBASIERTE POXVIRUS-IMPFSTOFFE

Title (fr)

IMMUNOCONJUGUÉS COMPRENANT DES PEPTIDES ISSUS DE POXVIRUS ET DES ANTICORPS DIRIGÉS CONTRE DES CELLULES PRÉSENTATRICES D'UN ANTIGÈNE POUR DES VACCINS CONTRE LES POXVIRUS À BASE DE SOUS-UNITÉ

Publication

EP 2496256 A4 20130717 (EN)

Application

EP 10828938 A 20101029

Priority

• US 25836909 P 20091105
• US 25872909 P 20091106
• US 75414010 A 20100405
• US 75474010 A 20100406
• US 37805910 P 20100830
• US 2010054668 W 20101029

Abstract (en)

[origin: WO2011056721A2] The present invention concerns methods and compositions for subunit-based vaccines for inducing immunity against poxvirus infections, such as smallpox. Preferred embodiments concern immunoconjugates comprising one or more subunit antigenic peptides attached to an antibody or fragment thereof that targets antigen-producing cells (APCs). More preferably, the antibody binds to HLA-DR and the antigenic peptide is from an immunomodulating factor, such as the viral IL-18 binding protein (vIL18BP). However, mixtures of antigenic peptides from different viral proteins may also be used. The vaccine is capable of inducing immunity against poxvirus without risk of disseminated infection in immunocompromised hosts or transmission to susceptible contacts.

IPC 8 full level

C07K 16/46 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61P 35/00 (2006.01); C07K 14/52 (2006.01); C07K 14/56 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/44 (2006.01)

CPC (source: EP)

A61K 47/646 (2017.07); A61K 47/6849 (2017.07); A61P 31/20 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/04 (2017.12); C07K 16/2896 (2013.01); C07K 2317/34 (2013.01)

Citation (search report)

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Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2011056721 A2 20110512; WO 2011056721 A3 20111013; AU 2010315432 A1 20120412; CA 2776563 A1 20110512; CN 102573902 A 20120711; EP 2496256 A2 20120912; EP 2496256 A4 20130717; IN 2692DEN2012 A 20150904

DOCDB simple family (application)

US 2010054668 W 20101029; AU 2010315432 A 20101029; CA 2776563 A 20101029; CN 201080047418 A 20101029; EP 10828938 A 20101029; IN 2692DEN2012 A 20120328