Global Patent Index - EP 2497486 A1

EP 2497486 A1 20120912 - Method for treating diseases caused by fungi associated with changes of qualitative and/quantitative composition of blood extracellular DNA

Title (en)

Method for treating diseases caused by fungi associated with changes of qualitative and/quantitative composition of blood extracellular DNA

Title (de)

VERFAHREN ZUR BEHANDLUNG VON KRANKHEITEN VERURSACHT VON PILZEN IM ZUSAMMENHANG MIT VERÄNDERUNGEN DER QUALITATIVEN UND/ODER QUANTITATIVEN ZUSAMMENSETZUNG VON EXTRAZELLULÄRER DNA IM BLUT

Title (fr)

MéTHODE DE TRAITEMENT DE MALADIES CAUSÉES PAR LES CHAMPIGNONS S'ACCOMPAGNANT D'ALTERATIONS DE LA COMPOSITION QUALITATIVE ET/OU& xA;QUANTITATIVE DE L'ADN EXTRACELLULAIRE DU SANG

Publication

EP 2497486 A1 20120912 (EN)

Application

EP 12170750 A 20040701

Priority

  • EP 04775224 A 20040701
  • RU 0300304 W 20030714
  • RU 2004108057 A 20040312

Abstract (en)

The invention relates to medicine and veterinary science and can be used for treating diseases associated with changes of the qualitative and/ quantitative composition of blood extracellular DNA, namely diseases provoked by fungi. The inventive method for treating the diseases consists in injecting an agent destroying blood extracellular DNA. DNAse enzyme injected into a systemic blood circulation in doses which modify the electrophoretic profile of the blood extracellular DNA definable by pulse-electrophoresis can be used in the form of an agent destroying said blood extracellular DNA. Said DNAse enzyme can be injected in doses and at regimes ensuring the level of a blood plasma DNA-hydrolytic activity which is measured in the blood plasma and is higher than 150 Kunitz units per litre of plasma during a total time higher than 12 hours a day.

IPC 8 full level

A61K 38/43 (2006.01); A61K 38/46 (2006.01); A61K 38/47 (2006.01); A61K 38/50 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); A61P 31/00 (2006.01)

IPC 8 main group level

A61K (2006.01)

CPC (source: EP US)

A61K 38/465 (2013.01 - EP US); A61P 3/10 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 31/00 (2017.12 - EP); C12Y 301/21001 (2013.01 - EP US)

Citation (applicant)

  • "Merck Manual of Diagnosis and Therapy"
  • K. LANCE GOULD: "New Concepts and Paradigms in Cardiovascular Medicine: The Noninvasive Management of Coronary Artery Disease", THE AMERICAN JOURNAL OF MEDICINE, vol. 104, 22 June 1998 (1998-06-22), pages 2S - 17S
  • GERARD EMILIEN: "Pharmacological Management of Diabetes: Recent Progress and Future Perspective in Daily Drug Treatment", PHARMACOL. THER., vol. 81, no. 1, 1999, pages 37 - 51, XP000876712, DOI: doi:10.1016/S0163-7258(98)00034-5
  • "Ser.Immunology and Medicine", vol. 29, 2001, KLUWER ACAD.PUBLISHERS, article "Therapeutic Immunosupression"
  • YOUSSOUFIAN H; PYERITZ RE: "Mechanisms and Consequences of Somatic Mosaicism in Humans", NATURE REVIEWS GENETICS, vol. 3, 2002, pages 748 - 758
  • CIZMAN M: "The use and resistance to antibiotics in the community", INT J ANTIMICROB AGENTS, 21 April 2003 (2003-04-21), pages 297 - 307
  • SEFTON A.M.: "Mechanisms of antimicrobial resistance: their clinical relevance in the new millennium", DRUGS, vol. 62, 2002, pages 557 - 66
  • PERLTM: "The threat of vancomycin resistance", AM J MED, vol. 106, May 1999 (1999-05-01), pages 26S - 37S
  • MAR MASIA CANUTO: "Antifimgal drug resistance to azoles and polyenes", THE LANCET INFECTIOUS DISEASES, vol. 2, no. 9, 1 September 2002 (2002-09-01), pages 550 - 563, XP004811129, DOI: doi:10.1016/S1473-3099(02)00371-7
  • JANE P. BARRETT: "A systematic review of the antifungal effectiveness and tolerability of amphotericin B formulations", CLINICAL THERAPEUTICS, vol. 25, no. 5, May 2003 (2003-05-01), pages 1295 - 1320
  • MOGHADASIAN MH: "A safety look at currently available statins.", EXPERT OPIN DRUG SAF, 1 September 2002 (2002-09-01), pages 269 - 74
  • CLEARFIELD MB: "Statins: balancing benefits, efficacy and safety", EXPERT OPIN PHARMACOTHER, 3 May 2002 (2002-05-03), pages 469 - 77
  • DEWITT DE; HIRSCH IB, JAMA, vol. 9, 28 May 2003 (2003-05-28), pages 2254 - 64
  • ROPER NA: "Cause-specific mortality in a population with diabetes: South Tees Diabetes Mortality Study.", DIABETES CARE, 25 January 2002 (2002-01-25), pages 43 - 8
  • GRAHAM RM: "Cyclosporine: mechanisms of action and toxicity.", CLEVE CLIN J MED, vol. 61, July 1994 (1994-07-01), pages 308 - 13
  • PONTICELLI C: "Renal transplantation, past, present and future.", J NEPHROL, vol. 12, no. 2, July 1999 (1999-07-01), pages 105 - 10
  • TOLKOFF-RUBIN NE; RUBIN RH: "Recent advances in the diagnosis and management of infection in the organ transplant recipient", SEMIN NEPHROL, 20 March 2000 (2000-03-20), pages 148 - 63
  • BECKINAN JA; CREAGER MA; LIBBY P: "Diabetes and atherosclerosis: epidemiology, pathophysiology, and management.", JAMA, vol. 7, 28 May 2002 (2002-05-28), pages 2570 - 81
  • EPSTEIN SE; ZHU J; BURNETT MS; ZHOU YF; VERCELLOTTI G; HAJJAR D: "Infection and atherosclerosis: potential roles of pathogen burden and molecular mimicry.", ARTERIOSCLER THROMB VASC BIOL, 20 June 2000 (2000-06-20), pages 1417 - 20, XP002343338
  • PIETROPAOLO M; BARINAS-MITCHELL E; PIETROPAOLO SL; KULLER LH; TRUCCO M: "Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes.", DIABETES, vol. 9, 4 January 2000 (2000-01-04), pages 32 - 8
  • LI X; KOLLTVEIT KM; TRONSTAD L; OLSEN I: "Systemic diseases caused by oral infection", CLIN MICROBIOL REV, 13 October 2000 (2000-10-13), pages 547 - 58
  • BERTONI AG; SAYDAH S; BRANCATI FL: "Diabetes and the risk of infection-related mortality in the U.S.", DIABETES CARE, vol. 6, 24 June 2001 (2001-06-24), pages 1044 - 9
  • SHUSTER A.M., SCIENCE, vol. 256, 1992, pages 665 - 667
  • BIGBEE W. ET AL., MUTATION RES., vol. 397, 1998, pages 119 - 136

Citation (search report)

  • [A] DE 4024530 A1 19920206 - KLINGER & CO DR [DE]
  • [A] WO 9728266 A1 19970807 - GENENTECH INC [US]
  • [A] SUGIHARA S ET AL: "Deoxyribonuclease treatment prevents blood-borne liver metastasis of cutaneously transplanted tumour cells in mice", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, LONDON, GB, vol. 67, no. 1, 1 January 1993 (1993-01-01), pages 66 - 70, XP008086562, ISSN: 0007-0920
  • [A] DAVIS J C JR ET AL: "Recombinant human Dnase I (rhDNase) in patients with lupus nephritis", LUPUS, BASINGSTOKE, GB, vol. 8, no. 1, 1 January 1999 (1999-01-01), pages 68 - 76, XP009124143, ISSN: 0961-2033, DOI: 10.1191/096120399678847380

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

EP 1661579 A2 20060531; EP 1661579 A4 20091125; EP 1661579 B1 20120606; EP 2497486 A1 20120912; EP 2497486 B1 20130807; EP 2497487 A1 20120912; EP 2497487 B1 20130807; EP 2497488 A1 20120912; EP 2497488 B1 20130807; ES 2388605 T3 20121016; ES 2433918 T3 20131213; ES 2434111 T3 20131213; ES 2434112 T3 20131213; PL 1661579 T3 20121130; PL 2497486 T3 20140131; PL 2497487 T3 20140131; PL 2497488 T3 20140131; RU 2004108057 A 20050927; RU 2269358 C2 20060210; US 2007104702 A1 20070510; WO 2005004789 A2 20050120; WO 2005004789 A3 20050324

DOCDB simple family (application)

EP 04775224 A 20040701; EP 12170750 A 20040701; EP 12170754 A 20040701; EP 12170757 A 20040701; ES 04775224 T 20040701; ES 12170750 T 20040701; ES 12170754 T 20040701; ES 12170757 T 20040701; PL 04775224 T 20040701; PL 12170750 T 20040701; PL 12170754 T 20040701; PL 12170757 T 20040701; RU 2004000260 W 20040701; RU 2004108057 A 20040312; US 56460904 A 20040701