EP 2501701 A1 20120926 - METHOD OF PRODUCING HIGHLY PURE PRASUGREL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
Title (en)
METHOD OF PRODUCING HIGHLY PURE PRASUGREL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
Title (de)
VERFAHREN ZUR HERSTELLUNG VON HOCHREINEM PRASUGREL UND PHARMAZEUTISCH AKZEPTABLEN SALZEN DARAUS
Title (fr)
PROCÉDÉ DE FABRICATION DE PRASUGREL HAUTEMENT PUR ET DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES
Publication
Application
Priority
- CZ 2009763 A 20091116
- CZ 2010000115 W 20101112
Abstract (en)
[origin: WO2011057592A1] A method for the production of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate of formula (I) or its salts, characterized in that the compound of formula (III) in the form of a salt with an arene sulfonic acid is reacted with the compound of formula (XV), wherein Y means: chlorine, bromine, or an OR4 group, wherein R4 means an alkane sulfonic group or arene sulfonic group, in an organic solvent in the presence of an inorganic base or organic base, to give, after addition of an acetylating reagent and organic base to the reaction mixture, the compound of formula (I), which, after addition of a co-solvent, is crystallized from the reaction mixture, and the compound of formula (I) is optionally purified by crystallization and optionally converted to a salt by reaction with an organic or inorganic acid in a suitable solvent. (Formulae (I), (III), (XV)
IPC 8 full level
C07D 495/04 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); C07D 495/04 (2013.01)
Citation (search report)
See references of WO 2011057592A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011057592 A1 20110519; CN 102612519 A 20120725; CZ 2009763 A3 20110525; EP 2501701 A1 20120926
DOCDB simple family (application)
CZ 2010000115 W 20101112; CN 201080051925 A 20101112; CZ 2009763 A 20091116; EP 10795910 A 20101112