EP 2501703 B1 20130918 - SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS
Title (en)
SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS
Title (de)
Spiropiperidinverbindungen als ORL-1-Rezeptorantagonisten
Title (fr)
Composés de spiropipéridine en tant qu'antagonistes du récepteur orl-1
Publication
Application
Priority
- EP 09382246 A 20091116
- US 29862910 P 20100127
- US 2010056180 W 20101110
- EP 10782482 A 20101110
Abstract (en)
[origin: WO2011060035A1] As ORL-1 receptor antagonist of the formula I, its uses, and methods for its preparation are described. ORL-1 antagonists are deemed to be useful; in the treatment of depression and/or the treatment of overweight, obesity, and/or weight maintenance post treatment for overweight or obesity. Certain compounds have also demonstrated through animal models that the compounds of the present invention are useful for the treatment of migraine.
IPC 8 full level
C07D 495/20 (2006.01); A61K 31/444 (2006.01); A61P 25/00 (2006.01)
CPC (source: EP KR US)
A61K 31/381 (2013.01 - KR); A61K 31/4436 (2013.01 - KR); A61P 3/04 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/06 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 495/20 (2013.01 - EP KR US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2011060035 A1 20110519; AR 078863 A1 20111207; AU 2010319581 A1 20120607; AU 2010319581 B2 20131219; AU 2010319581 C1 20140515; CA 2796161 A1 20110519; CA 2796161 C 20150317; CN 102612520 A 20120725; CN 102612520 B 20150408; CO 6541545 A2 20121016; CR 20130087 A 20130417; DK 2501703 T3 20131014; DO P2012000135 A 20120815; EA 020848 B1 20150227; EA 201290352 A1 20121030; EC SP12011902 A 20120731; EP 2501703 A1 20120926; EP 2501703 B1 20130918; ES 2435814 T3 20131223; HK 1169988 A1 20130215; HN 2012001011 A 20150831; HR P20130967 T1 20131122; IL 219370 A0 20120628; IL 219370 A 20150129; JO 2887 B1 20150315; JP 2013510859 A 20130328; JP 5680101 B2 20150304; KR 101363830 B1 20140214; KR 20130026523 A 20130313; MA 33751 B1 20121101; ME 01537 B 20140420; MX 2012005691 A 20120613; MY 160665 A 20170315; NZ 600006 A 20140530; PE 20121430 A1 20121026; PL 2501703 T3 20140228; PT 2501703 E 20131126; RS 53018 B 20140430; SI 2501703 T1 20131129; TW 201127841 A 20110816; TW I465453 B 20141221; UA 107943 C2 20150310; US 2011118251 A1 20110519; US 8232289 B2 20120731; ZA 201202967 B 20130925
DOCDB simple family (application)
US 2010056180 W 20101110; AR P100104035 A 20101102; AU 2010319581 A 20101110; CA 2796161 A 20101110; CN 201080051850 A 20101110; CO 12073055 A 20120504; CR 20130087 A 20130226; DK 10782482 T 20101110; DO 2012000135 A 20120511; EA 201290352 A 20101110; EC SP12011902 A 20120516; EP 10782482 A 20101110; ES 10782482 T 20101110; HK 12110735 A 20121026; HN 2012001011 A 20120511; HR P20130967 T 20131011; IL 21937012 A 20120423; JO P20100386 A 20101103; JP 2012538935 A 20101110; KR 20127012498 A 20101110; MA 34869 A 20120514; ME P11813 A 20101110; MX 2012005691 A 20101110; MY PI2012002117 A 20101110; NZ 60000610 A 20101110; PE 2012000659 A 20101110; PL 10782482 T 20101110; PT 10782482 T 20101110; RS P20130485 A 20101110; SI 201030388 T 20101110; TW 99138241 A 20101105; UA A201205367 A 20101110; US 94318710 A 20101110; ZA 201202967 A 20120423