EP 2509629 A1 20121017 - DOCK-AND-LOCK (DNL) COMPLEXES FOR DELIVERY OF INTERFERENCE RNA
Title (en)
DOCK-AND-LOCK (DNL) COMPLEXES FOR DELIVERY OF INTERFERENCE RNA
Title (de)
DOCK-AND-LOCK (DNL)-KOMPLEXE ZUR VERABREICHUNG VON INTERFERENZ-RNA
Title (fr)
COMPLEXES DNL (« DOCK-AND-LOCK ») DESTINÉS À L'ADMINISTRATION D'ARN INTERFÉRANT
Publication
Application
Priority
- US 26787709 P 20091209
- US 64414609 A 20091222
- US 30268210 P 20100209
- US 73178110 A 20100325
- US 75264910 A 20100401
- US 75474010 A 20100406
- US 86982310 A 20100827
- US 87134510 A 20100830
- US 91551510 A 20101029
- US 41459210 P 20101117
- US 94953610 A 20101118
- US 2010059660 W 20101209
Abstract (en)
[origin: WO2011072114A1] Described herein are compositions and methods of use of targeted delivery complexes for delivery of siRNA to a disease-associated cell, tissue or pathogen. The targeted delivery complex comprises a targeting molecule, such as an antibody or fragment thereof, conjugated to one or more siRNA carriers. In preferred embodiments the siRNA carrier is a dendrimer or protamine and the targeting molecule is an anti-cancer antibody, such as hRS7. More preferably, the antibody or fragment is rapidly internalized into the target cell to facilitate uptake of the siRNA. Most preferably, the targeted delivery complex is made by the DNL technique. The compositions and methods are of use to treat a variety of disease states, such as cancer, autoimmune disease, immune dysfunction, cardiac disease, neurologic disease, inflammatory disease or infectious disease.
IPC 8 full level
A61K 39/395 (2006.01); C07K 16/46 (2006.01); C12N 15/113 (2010.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 16/18 (2013.01); C07K 16/2803 (2013.01); C07K 16/2833 (2013.01); C07K 16/2887 (2013.01); C07K 16/30 (2013.01); C07K 16/303 (2013.01); C07K 16/3092 (2013.01); C07K 16/44 (2013.01); C07K 16/468 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/77 (2013.01); C07K 2319/70 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3513 (2013.01); C12N 2320/32 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011072114 A1 20110616; AU 2010328136 A1 20120517; AU 2010328136 B2 20160225; CA 2781717 A1 20110616; CA 2781717 C 20170912; CN 102665758 A 20120912; EP 2509629 A1 20121017; EP 2509629 A4 20130626
DOCDB simple family (application)
US 2010059660 W 20101209; AU 2010328136 A 20101209; CA 2781717 A 20101209; CN 201080052690 A 20101209; EP 10836672 A 20101209