EP 2512492 A1 20121024 - METHODS OF INHIBITING CATARACTS AND PRESBYOPIA
Title (en)
METHODS OF INHIBITING CATARACTS AND PRESBYOPIA
Title (de)
VERFAHREN ZUR HEMMUNG VON GRAUEM STAR UND ALTERSWEITSICHTIGKEIT
Title (fr)
PROCÉDÉS POUR EMPÊCHER DES CATARACTES ET LA PRESBYTIE
Publication
Application
Priority
- US 28613909 P 20091214
- US 35016110 P 20100601
- US 2010060044 W 20101213
Abstract (en)
[origin: WO2011075430A1] Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a ßL-crystallin electrostatic interaction inhibitor. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins, particularly ßL-crystallin. It has been found that the aggregation of ßL-crystallin is an electrostatic phenomenon and that electrostatic interaction inhibitors can be employed to prevent the formation of ßL-crystallin aggregates as well as to deaggregate already formed aggregates.
IPC 8 full level
A61K 33/14 (2006.01); A61P 27/10 (2006.01); A61P 27/12 (2006.01)
CPC (source: EP US)
A61K 31/14 (2013.01 - EP US); A61K 31/4164 (2013.01 - EP US); A61K 31/4425 (2013.01 - EP US); A61K 31/66 (2013.01 - EP US); A61K 31/675 (2013.01 - EP US); A61K 33/00 (2013.01 - EP US); A61K 33/14 (2013.01 - EP US); A61P 27/02 (2017.12 - EP); A61P 27/10 (2017.12 - EP); A61P 27/12 (2017.12 - EP)
Citation (search report)
See references of WO 2011075430A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011075430 A1 20110623; EP 2512492 A1 20121024; JP 2013513622 A 20130422; US 2012321675 A1 20121220; US 2014274962 A1 20140918; US 8758802 B2 20140624; US 9283237 B2 20160315
DOCDB simple family (application)
US 2010060044 W 20101213; EP 10795541 A 20101213; JP 2012543328 A 20101213; US 201013514185 A 20101213; US 201414274139 A 20140509