EP 2514407 A1 20121024 - Stable non-aqueous pharmaceutical compositions
Title (en)
Stable non-aqueous pharmaceutical compositions
Title (de)
Stabile nichtwässrige pharmazeutische Zusammensetzungen
Title (fr)
Compositions pharmaceutiques stables non aqueuses
Publication
Application
Priority
- EP 08760278 A 20080530
- EP 07109435 A 20070601
- EP 07114524 A 20070817
- EP 12159419 A 20080530
Abstract (en)
The present invention relates to shelf stable non-aqueous pharmaceutical compositions comprising a dehydrated therapeutically active polypeptide comprising 10-100 amino acids, at least one semi-polar protic organic solvent and which polypetide has been dehydrated at a target pH which is at least 1 pH unit distant from the pI. The composition can be used in methods of treating diabetes, hyperglycaemia and impaired glucose tolerance.
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/12 (2006.01); A61K 9/19 (2006.01); A61K 38/04 (2006.01); A61K 38/16 (2006.01); A61K 38/28 (2006.01); A61K 47/10 (2006.01); A61K 47/42 (2006.01)
CPC (source: EP KR US)
A61K 9/08 (2013.01 - EP KR US); A61K 9/1688 (2013.01 - EP US); A61K 38/16 (2013.01 - KR); A61K 38/22 (2013.01 - US); A61K 38/28 (2013.01 - EP KR US); A61K 47/10 (2013.01 - EP US); A61P 1/04 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/50 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61K 9/19 (2013.01 - EP US)
Citation (applicant)
- WO 0042993 A2 20000727 - MASSACHUSETTS INST TECHNOLOGY [US]
- WO 2008034881 A1 20080327 - NOVO NORDISK AS [DK], et al
- EP 0792290 A1 19970903 - NOVO NORDISK AS [DK]
- EP 0214826 A2 19870318 - NOVO INDUSTRI AS [DK]
- EP 0705275 A1 19960410 - NOVO NORDISK AS [DK]
- US 5504188 A 19960402 - BAKER JEFFREY C [US], et al
- EP 0368187 A2 19900516 - HOECHST AG [DE]
- US 5750497 A 19980512 - HAVELUND SVEND [DK], et al
- US 6011007 A 20000104 - HAVELUND SVEND [DK], et al
- EP 0375437 A2 19900627 - NOVO NORDISK AS [DK]
- EP 0383472 A2 19900822 - LILLY CO ELI [US]
- WO 9507931 A1 19950323 - NOVO NORDISK AS [DK], et al
- WO 2005054291 A1 20050616 - NOVO NORDISK AS [DK], et al
- WO 2006018450 A2 20060223 - NOVO NORDISK AS [DK], et al
- WO 03078538 A1 20030925 - BESPAK PLC [GB], et al
- US 5957895 A 19990928 - SAGE BURTON H [US], et al
- US 5858001 A 19990112 - TSALS IZRAIL [US], et al
- US 4468221 A 19840828 - MAYFIELD WILLIAM B [US]
- US 4468 A 18460425
- US 221 A 18370603
- US 6074 A 18490130
- US 5527288 A 19960618 - GROSS JOSEPH [IE], et al
- US 6074369 A 20000613 - SAGE BURTON H [US], et al
- J. T. CHIN; S. L. WHEELER; A. M. KLIBANOV: "Communication to the editor: On protein solubility in organic solvents", BIOTECHNOL.BIOENG., vol. 44, no. 1, 1994, pages 140 - 145
- HUDSON; ANDERSEN, PEPTIDE SCIENCE, vol. 76, no. 4, 2004, pages 298 - 308
- GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
- NAIKI ET AL., ANAL. BIOCHEM., vol. 177, 1989, pages 244 - 249
- LEVINE, METHODS.ENZYMOL., vol. 309, 1999, pages 274 - 284
- NIELSEN ET AL., BIOCHEMISTRY, vol. 40, 2001, pages 6036 - 6046
Citation (search report)
- [I] WO 2007047948 A2 20070426 - NASTECH PHARM CO [US], et al
- [I] US 5981489 A 19991109 - STEVENSON CYNTHIA L [US], et al
- [I] WO 2005115441 A2 20051208 - NASTECH PHARM CO [US], et al
- [I] WO 9419020 A1 19940901 - GENENTECH INC [US], et al
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008145730 A1 20081204; AU 2008257505 A1 20081204; AU 2008257505 B2 20130516; BR PI0812354 A2 20150127; CA 2716159 A1 20081204; CN 101677944 A 20100324; EP 2164458 A1 20100324; EP 2164459 A1 20100324; EP 2497462 A1 20120912; EP 2514407 A1 20121024; JP 2010529004 A 20100826; JP 2010529956 A 20100902; JP 5628026 B2 20141119; JP 5675347 B2 20150225; KR 20100017667 A 20100216; MX 2009012789 A 20091210; RU 2009146883 A 20110720; RU 2472492 C2 20130120; US 2010144592 A1 20100610; US 2010190706 A1 20100729; US 2014349924 A1 20141127; WO 2008145732 A1 20081204
DOCDB simple family (application)
EP 2008056689 W 20080530; AU 2008257505 A 20080530; BR PI0812354 A 20080530; CA 2716159 A 20080530; CN 200880017599 A 20080530; EP 08760278 A 20080530; EP 08760287 A 20080530; EP 12159415 A 20080530; EP 12159419 A 20080530; EP 2008056699 W 20080530; JP 2010509834 A 20080530; JP 2010509835 A 20080530; KR 20097025474 A 20080530; MX 2009012789 A 20080530; RU 2009146883 A 20080530; US 201414336562 A 20140721; US 60134508 A 20080530; US 60188408 A 20080530