EP 2515661 A1 20121031 - IMMUNOPROTECTION BY ORAL ADMINISTRATION OF RECOMBINANT LACTOCOCCUS LACTIS MINI-CAPSULES
Title (en)
IMMUNOPROTECTION BY ORAL ADMINISTRATION OF RECOMBINANT LACTOCOCCUS LACTIS MINI-CAPSULES
Title (de)
IMMUNSCHUTZ DURCH ORALE VERABREICHUNG VON MINIKAPSELN MIT REKOMBINANTEM LACTOCOCCUS LACTIS
Title (fr)
IMMUNOPROTECTION PAR ADMINISTRATION ORALE DE MINICAPSULES DE LACTOCOCCUS LACTIS RECOMBINANT
Publication
Application
Priority
- US 28966309 P 20091223
- US 2010041792 W 20100713
- US 2010062034 W 20101223
Abstract (en)
[origin: WO2011079282A1] In one embodiment, the present invention provides for an edible mini-capsule form of live, non-persisting, recombinant Lactococcus lactis (L.lactis) vaccine against a pathogen such as the highly virulent influenza H5N1 strain. Enteric coated capsule of the present invention induced high levels of hemagglutinin-specific serum IgG and fecal IgA antibody production after oral administration in mice and chickens, and rendered complete protection against a lethal challenge of H5N1 virus in mice. The present invention thus demonstrates a broadly applicable platform technology for producing and administering edible vaccines against bacterial and viral infections.
IPC 8 full level
A61K 39/145 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61P 31/16 (2017.12); A61K 2039/522 (2013.01); A61K 2039/523 (2013.01); A61K 2039/542 (2013.01); C12N 2760/16134 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011079282 A1 20110630; CN 102665422 A 20120912; CN 102665422 B 20150128; EP 2515661 A1 20121031; EP 2515661 A4 20131113; JP 2013515490 A 20130509
DOCDB simple family (application)
US 2010062034 W 20101223; CN 201080058158 A 20101223; EP 10840176 A 20101223; JP 2012546239 A 20101223