EP 2516384 A1 20121031 - NOVEL METHOD FOR THE PREPARATION OF (S)-PREGABALIN
Title (en)
NOVEL METHOD FOR THE PREPARATION OF (S)-PREGABALIN
Title (de)
NEUES VERFAHREN ZUR HERSTELLUNG VON (S)-PREGABALIN
Title (fr)
NOUVEAU PROCÉDÉ POUR LA PRÉPARATION DE LA (S)-PRÉGABALINE
Publication
Application
Priority
- ES 200931267 A 20091224
- EP 2010070634 W 20101223
Abstract (en)
[origin: WO2011076915A1] Method for the preparation of a salt (III) of pregabalin and (S)-mandelic acid with a (S, S) diastereomer content greater than 80% which comprises the following steps: (a) Hofmann reaction of (±)-3-(carbamoylmethyl)-5- methylhexanoic acid (I) to obtain racemic pregabalin (II), (b) addition of (S)-(+)-mandelic acid to obtain the corresponding diastereoisomeric salt (III) with a (S, S) diastereomer content greater than 80% (c)optionally, purification of the salt obtained in step (b); characterized in that step(b) is performed without isolating the product obtained in step(a).
IPC 8 full level
C07C 229/08 (2006.01)
CPC (source: EP ES)
C07C 227/34 (2013.01 - EP ES); C07C 235/74 (2013.01 - ES)
C-Set (source: EP)
Citation (search report)
See references of WO 2011076915A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011076915 A1 20110630; WO 2011076915 A8 20111103; EP 2516384 A1 20121031; ES 2362913 A1 20110715; ES 2362913 B1 20120524
DOCDB simple family (application)
EP 2010070634 W 20101223; EP 10801165 A 20101223; ES 200931267 A 20091224