EP 2519814 A1 20121107 - METHOD FOR THE COMPARATIVE ANALYSIS OF PROTEIN PREPARATIONS BY MEANS OF NUCLEAR MAGNETIC RESONANCE
Title (en)
METHOD FOR THE COMPARATIVE ANALYSIS OF PROTEIN PREPARATIONS BY MEANS OF NUCLEAR MAGNETIC RESONANCE
Title (de)
VERFAHREN ZUR VERGLEICHENDEN ANALYSE VON PROTEINZUBREITUNGEN MITTELS KERNMAGNETRESONANZ
Title (fr)
METHODE D'ANALYSE COMPARATIVE DE PREPARATIONS PROTEIQUES PAR RESONANCE MAGNETIQUE NUCLEAIRE
Publication
Application
Priority
- FR 0906427 A 20091231
- FR 2010052936 W 20101230
Abstract (en)
[origin: WO2011080492A1] The invention relates to a method for the comparative analysis and control of the quality of a protein preparation by means of nuclear magnetic resonance (NMR) spectrometry. This method can be used to compare three-dimensional protein conformations in different protein preparations without requiring the samples to undergo any particular preparation. In particular, the method can be used to determine if a selected protein is in the same three-dimensional conformation in different protein preparations, if it is degraded in the formulation or if it is interacting with some of the excipients present. Specifically, the method can be used for the analysis and control of the quality of therapeutic compounds, particularly biodrugs or biosimilars, in different samples, without altering said samples.
IPC 8 full level
G01N 24/08 (2006.01); G01R 33/46 (2006.01); G01R 33/465 (2006.01)
CPC (source: EP US)
G01N 24/08 (2013.01 - EP US); G01N 24/087 (2013.01 - EP US); G01R 33/4633 (2013.01 - EP US); G01R 33/465 (2013.01 - EP US)
Citation (search report)
See references of WO 2011080492A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
FR 2954830 A1 20110701; CA 2786170 A1 20110707; EP 2519814 A1 20121107; US 2013069646 A1 20130321; WO 2011080492 A1 20110707; WO 2011080492 A4 20141127
DOCDB simple family (application)
FR 0906427 A 20091231; CA 2786170 A 20101230; EP 10812874 A 20101230; FR 2010052936 W 20101230; US 201013520262 A 20101230