Global Patent Index - EP 2527837 A1

EP 2527837 A1 20121128 - Methods of inhibiting cell death or inflammation in a mammal

Title (en)

Methods of inhibiting cell death or inflammation in a mammal

Title (de)

Verfahren zur Verhinderung von Zelltod oder -entzündung bei Säugetieren

Title (fr)

Procédés d'inhibition de mort cellulaire ou inflammation chez un mammifère

Publication

EP 2527837 A1 20121128 (EN)

Application

EP 12154747 A 20051004

Priority

  • EP 05802454 A 20051004
  • US 71451104 P 20041004
  • US 70905305 P 20050816

Abstract (en)

In one aspect the present invention provides methods for inhibiting cell death or inflammation in a mammal, wherein the methods each include the step of administering to a mammal a Bcl protein in an amount sufficient to inhibit cell death or inflammation in the mammal. The invention also provides methods for identifying a Bcl protein that inhibits cell death or inflammation when administered to a mammal.

IPC 8 full level

G01N 33/50 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01)

CPC (source: EP US)

A61K 38/1709 (2013.01 - EP US); A61P 9/10 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); G01N 33/5088 (2013.01 - EP US)

Citation (applicant)

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  • S. CORY ET AL., ONCOGENE, vol. 22, 2003, pages 8590 - 8607
  • A. KARSAN ET AL., BLOOD, vol. 87, no. 8, 15 April 1996 (1996-04-15), pages 3089 - 3096
  • S.S. CHOI ET AL., MAMMALIAN GENOME, vol. 8, 1997, pages 781 - 782
  • L.H. BOISE ET AL., CELL, vol. 74, no. 4, 27 August 1993 (1993-08-27), pages 597 - 608
  • L. GIBSON ET AL., ONCOGENE, vol. 13, no. 4, 15 August 1996 (1996-08-15), pages 665 - 675
  • NEEDLEMAN; WUNSCH, J. MOL, BIOL., vol. 48, pages 443 - 5
  • HENIKOFF, S.; HENIKOFF, J. G., PROC. NAT'L ACAD. SCI. USA, vol. 89, 1992, pages 10915 - 10919
  • IWATA, A. ET AL., BLOOD, vol. 100, 2002, pages 2077
  • PALAZZO, A.J., AM. J. PHYSIOL., vol. 275, 1998, pages H2300
  • PIOT, C, CIRCULATION, vol. 96, 1997, pages 1598
  • DAEMEN, M., J. CLIN. INVEST., vol. 104, 1999, pages 541
  • VUKICEVIC, S., J. CLIN. INVEST., vol. 102, 1998, pages 202
  • CURSIO, R., FASEB J., vol. 13, 1999, pages 253
  • KOWALSKI, T.F., J. APPL. PHYSIOL., vol. 68, 1990, pages 125
  • IWATA ET AL., BLOOD, vol. 100, 2002, pages 2077
  • PIOT, C., CIRCULATION, vol. 96, 1997, pages 1598
  • NAMURA, S., J NEUROSCI., vol. 18, 1998, pages 3659
  • NODA, T., AM, J PHYSIOL., vol. 274, 1998, pages G270
  • CURSIO, R., FASEB J, vol. 13, 1999, pages 253
  • "Remington's Pharmaceutical Sciences", MAACK PUBLISHING CO
  • V.H.L. LEE, CRIT. REV. THER. DRUG CARRIER SYST., vol. 5, 1988, pages 69
  • V.H.L. LEE, J. CONTROLLED RELEASE, vol. 13, 1990, pages 213
  • V.H.L. LEE: "Peptide and Protein Drug Delivery", 1991, MARCEL DEKKER
  • DEBOER, A.G. ET AL., J. CONTROLLED RELEASE, vol. 13, 1990, pages 241
  • LEE, W.A., BIOPHARM., 22 November 1990 (1990-11-22)
  • FUERTGES, F. ET AL., J CONTROLLED RELEASE, vol. 11, 1990, pages 139
  • BAE, Y.H. ET AL., J CONTROLLED RELEASE, vol. 9, 1989, pages 271
  • HORI, R., PHARM. RES., vol. 6, 1989, pages 813
  • YAMAKAWA, I. ET AL., J. PHARM., SCI., vol. 79, 1990, pages 505
  • YOSHIHIRO, I. ET AL., J. CONTROLLED RELEASE, vol. 10, 1989, pages 195
  • ASANO, M. ET AL., J. CONTROLLED RELEASE, vol. 9, 1989, pages 111
  • ROSENBLATT, J., J. CONTROLLED RELEASE, vol. 9, 1989, pages 195
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  • TAKAKURA, Y. ET AL., J. <PHARM. SCI., vol. 78, 1989, pages 117
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  • LAGASSC, E.; WEISSMAN, I.L., J. EXP. MED., vol. 179, 1994, pages 1047
  • STRASSER, A. ET AL., CELL, vol. 67, 1991, pages 889
  • STRASSER, A., PROC, NATL. ACAD SCI., vol. 88, 1991, pages 8661
  • HITOSHI, Y. ET AL., IMMUNITY, vol. 8, 1998, pages 461
  • ONISHI, M. ET AL., EXP. HEMATOL., vol. 24, 1996, pages 324
  • PALAZZO, A.J. ET AL., AM. J. PHYSIOL., vol. 275, 1998, pages H2300

Citation (search report)

  • [XI] WO 9730083 A1 19970821 - CIBA GEIGY AG [CH], et al
  • [I] CRAXTON ANDREW ET AL: "The CD40-inducible Bcl-2 family member A1 protects B cells from antigen receptor-mediated apoptosis", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 200, no. 1, 25 February 2000 (2000-02-25), pages 56 - 62, XP002526950, ISSN: 0008-8749, DOI: 10.1006/CIMM.2000.1616
  • [I] CHUANG PETER I ET AL: "A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 249, no. 2, 19 August 1998 (1998-08-19), pages 361 - 365, XP002685460, ISSN: 0006-291X
  • [I] KIM JIN KOO ET AL: "Up-regulation of Bfl-1/A1 via NF-kappaB activation in cisplatin-resistant human bladder cancer cell line", CANCER LETTERS, vol. 212, no. 1, 20 August 2004 (2004-08-20), pages 61 - 70, XP002685461, ISSN: 0304-3835
  • [I] KARSAN ALY ET AL: "Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 44, 1996, pages 27201 - 27204, XP002685462, ISSN: 0021-9258
  • [ID] KARSAN ALY ET AL: "Cloning of a human Bcl-2 homologue: Inflammatory cytokines induced human A1 in cultured endothelial cells", BLOOD, vol. 87, no. 8, 1996, pages 3089 - 3096, XP002685463, ISSN: 0006-4971
  • [I] HU XIAOLONG ET AL: "Lipopolysaccharide induces the antiapoptotic molecules, Al and A20, in microvascular endothelial cells", BLOOD, vol. 92, no. 8, 15 October 1998 (1998-10-15), pages 2759 - 2765, XP002685464, ISSN: 0006-4971

Citation (examination)

CANTARA S ET AL: "Exogenous BH4/Bcl-2 peptide reverts coronary endothelial cell apoptosis induced by oxidative stress", JOURNAL OF VASCULAR RESEARCH, vol. 41, no. 2, 2004, pages 202 - 207, ISSN: 1018-1172

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

DOCDB simple family (publication)

WO 2006041835 A2 20060420; WO 2006041835 A3 20070531; AU 2005294453 A1 20060420; AU 2005294453 B2 20110120; CA 2583004 A1 20060420; EP 1796714 A2 20070620; EP 1796714 A4 20091104; EP 2527837 A1 20121128; JP 2008515803 A 20080515; JP 4885861 B2 20120229; US 2011082072 A1 20110407; US 2011312901 A1 20111222; US 2013053329 A1 20130228; US 7964565 B2 20110621; US 8304389 B2 20121106

DOCDB simple family (application)

US 2005035666 W 20051004; AU 2005294453 A 20051004; CA 2583004 A 20051004; EP 05802454 A 20051004; EP 12154747 A 20051004; JP 2007534888 A 20051004; US 201113107866 A 20110513; US 201213661411 A 20121026; US 57659105 A 20051004