EP 2536438 A1 20121226 - COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION
Title (en)
COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION
Title (de)
ZUSAMMENSETZUNG ZUR BEHANDLUNG VON LEBERKREBS BEI MENSCHEN AUF DER BASIS VON RHENIUM-188 UND VERFAHREN FÜR DIE ZUBEREITUNG EINER DERARTIGEN ZUSAMMENSETZUNG
Title (fr)
COMPOSITION POUR LE TRAITEMENT DU CANCER DU FOIE CHEZ L'HOMME A BASE DE RHENIUM-188 ET PROCEDE DE PREPARATION D'UNE TELLE COMPOSITION
Publication
Application
Priority
- FR 1000681 A 20100218
- EP 2011052420 W 20110218
Abstract (en)
[origin: WO2011101436A1] Liver cancer in humans is the fifth most common cancer in the world. Chemoembolization is an alternative strategy to surgery and radiotherapy that is attractive due to the effectiveness thereof and the limitation of side-effects for the patient. Formulations according to prior art have problems of stability and effectiveness which limit the clinical use thereof. The present invention therefore relates to a composition for treating liver cancer in humans including a complex of the following formula (I): [M(RCS3)2(RCS2)] where M is 188Re with high activity, that is to say greater than 3.7 Gbq, and a lipophilic organic base emulsified with an aqueous phase, R is an alkyl, cycloalkyl or aryl group, unsubstituted or substituted with one or more substituents selected from among halogen atoms, a hydroxyl group, alkyl groups and alkoxy groups.
IPC 8 full level
A61K 51/04 (2006.01); A61K 103/10 (2006.01)
CPC (source: EP KR)
A61K 31/10 (2013.01 - KR); A61K 51/04 (2013.01 - KR); A61K 51/0404 (2013.01 - EP); A61K 51/0474 (2013.01 - EP); A61P 1/16 (2017.12 - EP); A61P 35/00 (2017.12 - EP)
Citation (search report)
See references of WO 2011101436A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
FR 2956325 A1 20110819; FR 2956325 B1 20130315; CN 103153349 A 20130612; EP 2536438 A1 20121226; EP 2536438 B1 20131204; KR 20120120990 A 20121102; RU 2012134282 A 20140327; RU 2543342 C2 20150227; WO 2011101436 A1 20110825
DOCDB simple family (application)
FR 1000681 A 20100218; CN 201180019759 A 20110218; EP 11705507 A 20110218; EP 2011052420 W 20110218; KR 20127023890 A 20110218; RU 2012134282 A 20110218