EP 2537857 A3 20130102 - Mutant forms of streptolysin O
Title (en)
Mutant forms of streptolysin O
Title (de)
Mutante Formen von Streptolysin O
Title (fr)
Formes mutantes de streptolysine O
Publication
Application
Priority
- EP 08864055 A 20081218
- US 1619307 P 20071221
- US 8838108 P 20080813
Abstract (en)
[origin: US2009162392A1] Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S. pyogenes.
IPC 8 full level
C07K 14/315 (2006.01); A61K 38/17 (2006.01); A61K 39/09 (2006.01)
CPC (source: CN EP KR US)
A61K 39/09 (2013.01 - KR); A61K 39/092 (2013.01 - CN EP US); A61P 31/04 (2017.12 - EP); A61P 31/12 (2017.12 - EP); C07K 14/00 (2013.01 - KR); C07K 14/315 (2013.01 - CN EP KR US); A61K 38/00 (2013.01 - CN); A61K 2039/541 (2013.01 - CN); A61K 2039/545 (2013.01 - CN); A61K 2039/55505 (2013.01 - EP US); A61K 2039/55566 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP US)
Citation (search report)
- [Y] WO 2005108419 A1 20051117 - KIRKHAM LEA-ANN [GB], et al
- [Y] WO 9305155 A1 19930318 - BECKMAN INSTRUMENTS INC [US]
- [A] GB 2233977 A 19910123 - KEHOE MICHAEL, et al
- [A] WO 2004078907 A2 20040916 - INTERCELL AG [AT], et al
- [A] US 5523205 A 19960604 - COSSART PASCALE [FR], et al
- [A] WO 9949049 A1 19990930 - MOUNT SINAI HOSPITAL CORP [CA], et al
- [XP] WO 2008108830 A2 20080912 - NOVARTIS AG [US], et al
- [XP] WO 2007144647 A2 20071221 - MITCHELL TIMOTHY JOHN [GB], et al
- [Y] PINKNEY M ET AL.: "The Thiol-Activated Toxin Streptolysin O Does Not Require a Thiol Group for Cytolytic Activity", INFECTION AND IMMUNITY, vol. 57, no. 8, August 1989 (1989-08-01), pages 2553 - 2558, XP002521254
- [A] PALMER M ET AL: "Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization", THE EMBO JOURNAL, vol. 17, no. 6, 1998, pages 1598 - 1605, XP002529266
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2009162392 A1 20090625; US 7731978 B2 20100608; AU 2008339551 A1 20090702; AU 2008339551 B2 20131024; BR PI0821240 A2 20190514; BR PI0821240 B1 20200915; BR PI0821240 B8 20210525; BR PI0821240 B8 20221004; CA 2709927 A1 20090702; CA 2709927 C 20170516; CN 101977926 A 20110216; CN 101977926 B 20141008; CN 104292312 A 20150121; DK 2235046 T3 20121029; EP 2235046 A2 20101006; EP 2235046 B1 20120801; EP 2537857 A2 20121226; EP 2537857 A3 20130102; EP 2537857 B1 20170118; ES 2391695 T3 20121129; JP 2011507500 A 20110310; JP 2014027946 A 20140213; JP 5656642 B2 20150121; KR 101773114 B1 20170830; KR 20100113089 A 20101020; KR 20160114196 A 20161004; NZ 586430 A 20120928; NZ 601543 A 20130328; PL 2235046 T3 20121231; PT 2235046 E 20121026; RU 2010130338 A 20120127; RU 2498994 C2 20131120; US 2010158935 A1 20100624; US 2012003258 A1 20120105; US 8039005 B2 20111018; US 8409589 B2 20130402; WO 2009081274 A2 20090702; WO 2009081274 A3 20090813
DOCDB simple family (application)
US 33936508 A 20081219; AU 2008339551 A 20081218; BR PI0821240 A 20081218; CA 2709927 A 20081218; CN 200880126781 A 20081218; CN 201410460591 A 20081218; DK 08864055 T 20081218; EP 08864055 A 20081218; EP 12178329 A 20081218; ES 08864055 T 20081218; IB 2008003725 W 20081218; JP 2010538946 A 20081218; JP 2013211628 A 20131009; KR 20107016353 A 20081218; KR 20167026224 A 20081218; NZ 58643008 A 20081218; NZ 60154308 A 20081218; PL 08864055 T 20081218; PT 08864055 T 20081218; RU 2010130338 A 20081218; US 201113232764 A 20110914; US 71186910 A 20100224