EP 2542548 A1 20130109 - PROCESS FOR PREPARATION OF POLYMORPHIC FORM AND NEW POLYMORPHIC FORM OF IMATINIB MESYLATE ISOLATED IN THAT PROCESS
Title (en)
PROCESS FOR PREPARATION OF POLYMORPHIC FORM AND NEW POLYMORPHIC FORM OF IMATINIB MESYLATE ISOLATED IN THAT PROCESS
Title (de)
VERFAHREN ZUR HERSTELLUNG EINER POLYMORPHEN FORM UND NEUE, IN DIESEM VERFAHREN ISOLIERTE POLYMORPHE FORM VON IMATINIB-MESYLAT
Title (fr)
PROCÉDÉ POUR LA PRÉPARATION DE FORME POLYMORPHE ET NOUVELLE FORME POLYMORPHE D'IMATINIB MÉSYLATE ISOLÉE DANS CE PROCÉDÉ
Publication
Application
Priority
- PL 39061110 A 20100304
- PL 2011000028 W 20110304
Abstract (en)
[origin: WO2011108953A1] In the present invention, the process of preparation of imatinib mesylate polymorphic form a, in the reaction of equimolar amounts of imatinib base and methanesulfonic acid in the mixture of isopropyl alcohol and diisopropyl ether or in methylene dichloride is disclosed. According to the present invention polymorphic form a of imatinib mesylate is obtained as microcrystalline form or granulated form characterized by high bulk density. The present invention also relates to new polymorphic form N of imatinib mesylate and its use in the process of preparation of polymorphic form a.
IPC 8 full level
C07D 401/04 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07D 401/04 (2013.01)
Citation (search report)
See references of WO 2011108953A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011108953 A1 20110909; EP 2542548 A1 20130109; PL 390611 A1 20110912
DOCDB simple family (application)
PL 2011000028 W 20110304; EP 11715079 A 20110304; PL 39061110 A 20100304