EP 2552892 A1 20130206 - EFFICIENT SYNTHESIS FOR THE PREPARATION OF MONTELUKAST AND NOVEL CRYSTALLINE FORM OF INTERMEDIATES THEREIN
Title (en)
EFFICIENT SYNTHESIS FOR THE PREPARATION OF MONTELUKAST AND NOVEL CRYSTALLINE FORM OF INTERMEDIATES THEREIN
Title (de)
EFFIZIENTE SYNTHESE ZUR HERSTELLUNG VON MONTELUKAST UND NEUE KRISTALLINE FORM VON ZWISCHENPRODUKTEN DARIN
Title (fr)
SYNTHÈSE EFFICACE POUR LA PRÉPARATION DE MONTÉLUKAST ET NOUVELLE FORME CRISTALLINE D'INTERMÉDIAIRES DANS CELLE-CI
Publication
Application
Priority
- SI 201000287 A 20100917
- EP 10003612 A 20100331
- EP 2011055050 W 20110331
- EP 11713229 A 20110331
Abstract (en)
[origin: WO2011121091A1] The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.
IPC 8 full level
C07D 215/18 (2006.01)
CPC (source: EP)
C07D 215/18 (2013.01)
Citation (search report)
See references of WO 2011121091A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2011055050 W 20110331; EP 11713229 A 20110331