EP 2556070 A1 20130213 - SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES
Title (en)
SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES
Title (de)
SYNTHESE CHIRALER 2-(1H-INDAZOL-6-YL)-SPIRO-[CYCLOPROPAN-1,3'- INDOLIN]-2'-ONE
Title (fr)
SYNTHÈSE DE 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES CHIRALES
Publication
Application
Priority
- CA 2010000518 W 20100406
- US 32133210 P 20100406
- US 32132910 P 20100406
- CA 2011000387 W 20110406
Abstract (en)
[origin: WO2011123946A1] The invention is directed to a compound represented by the following structural formula pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
IPC 8 full level
C07D 413/14 (2006.01); A61K 31/5377 (2006.01); A61P 35/00 (2006.01); C07D 231/56 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01)
CPC (source: EP KR US)
A61K 31/404 (2013.01 - KR); A61K 31/416 (2013.01 - KR); A61K 31/5377 (2013.01 - EP KR US); A61K 45/06 (2013.01 - KR US); A61P 1/00 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); C07D 231/56 (2013.01 - EP KR US); C07D 403/04 (2013.01 - EP KR US); C07D 403/10 (2013.01 - EP KR US); C07D 403/14 (2013.01 - EP KR US); C07D 413/14 (2013.01 - EP KR US); A61K 2300/00 (2013.01 - KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011123946 A1 20111013; WO 2011123946 A8 20111208; AU 2011238384 A1 20120927; AU 2011238384 B2 20150219; BR 112012025496 A2 20200818; BR 112012025496 B1 20210223; CN 102892766 A 20130123; CN 102892766 B 20150520; CY 1118610 T1 20170712; DK 2556071 T3 20161212; EA 023173 B1 20160429; EA 201270752 A1 20130430; EP 2556070 A1 20130213; EP 2556070 A4 20131023; EP 2556070 B1 20170607; EP 2556071 A1 20130213; EP 2556071 A4 20130904; EP 2556071 B1 20160817; ES 2603613 T3 20170228; ES 2639757 T3 20171030; HR P20161498 T1 20161216; HU E030651 T2 20170529; IL 221556 A 20150430; JP 2013523784 A 20130617; JP 5442906 B2 20140319; KR 101782668 B1 20170927; KR 20130108065 A 20131002; LT 2556071 T 20170125; ME 02545 B 20170220; MX 2012011516 A 20130308; NZ 602350 A 20140530; PL 2556071 T3 20170228; PT 2556071 T 20161122; SG 183875 A1 20121030; SI 2556071 T1 20161230; SM T201600430 B 20170110; TW 201134471 A 20111016; TW I516262 B 20160111; US 10077255 B2 20180918; US 10358436 B2 20190723; US 2011263598 A1 20111027; US 2012264800 A1 20121018; US 2013096301 A1 20130418; US 2014045838 A1 20140213; US 2015133677 A1 20150514; US 2016045511 A1 20160218; US 2017226088 A1 20170810; US 2018105511 A1 20180419; US 2018282306 A1 20181004; US 8263596 B2 20120911; US 8481533 B2 20130709; US 8921545 B2 20141230; US 9139563 B2 20150922; US 9579327 B2 20170228; US 9796703 B2 20171024; US 9907800 B2 20180306; WO 2011123947 A1 20111013; WO 2011123947 A8 20111222
DOCDB simple family (application)
CA 2011000386 W 20110406; AU 2011238384 A 20110406; BR 112012025496 A 20110406; CA 2011000387 W 20110406; CN 201180018148 A 20110406; CY 161101184 T 20161117; DK 11764988 T 20110406; EA 201270752 A 20110406; EP 11764988 A 20110406; EP 11764989 A 20110406; ES 11764988 T 20110406; ES 11764989 T 20110406; HR P20161498 T 20161114; HU E11764988 A 20110406; IL 22155612 A 20120821; JP 2013502966 A 20110406; KR 20127029064 A 20110406; LT 11764988 T 20110406; ME P26516 A 20110406; MX 2012011516 A 20110406; NZ 60235011 A 20110406; PL 11764988 T 20110406; PT 11764988 T 20110406; SG 2012065090 A 20110406; SI 201131015 A 20110406; SM 201600430 T 20161124; TW 100111767 A 20110406; US 201113081254 A 20110406; US 201113639648 A 20110406; US 201213529542 A 20120621; US 201313935021 A 20130703; US 201414580658 A 20141223; US 201514823057 A 20150811; US 201715440548 A 20170223; US 201715790847 A 20171023; US 201815902143 A 20180222