Global Patent Index - EP 2556079 A4

EP 2556079 A4 20131009 - POLYOL MODIFIED AMINOGLYCOSIDE-LIPID CONJUGATES

Title (en)

POLYOL MODIFIED AMINOGLYCOSIDE-LIPID CONJUGATES

Title (de)

DURCH POLYOLE MODIFIZIERTE AMINOGLYCOSID-LIPID-KONJUGATE

Title (fr)

CONJUGUÉS AMINOGLYCOSIDE-LIPIDE MODIFIÉS PAR UN POLYOL

Publication

EP 2556079 A4 20131009 (EN)

Application

EP 11765147 A 20110405

Priority

  • US 32143610 P 20100406
  • IB 2011001226 W 20110405

Abstract (en)

[origin: WO2011124986A2] In some aspects, the present invention provides novel aminoglycoside derivatives that exhibit antibacterial activity. In some aspects, the aminoglycoside derivative comprising (a) an aminoglycoside group; and (b) at least one carbamate group or alkoxy group attached to a primary or secondary hydroxy position of the aminoglycoside group; or a salt thereof. In some embodiments, the hydrophobic group is a carbamate or an ether group. Additionally, methods of treating and preventing bacterial infections using these aminoglycoside derivatives are also provided.

IPC 8 full level

C07H 15/00 (2006.01); A61K 31/7036 (2006.01); A61P 31/04 (2006.01); C07H 13/02 (2006.01); C07H 13/12 (2006.01); C07H 15/04 (2006.01); C07H 15/12 (2006.01); C07H 15/18 (2006.01)

CPC (source: EP US)

A61P 31/04 (2017.12 - EP); C07H 15/224 (2013.01 - US); C07H 17/04 (2013.01 - EP US)

Citation (search report)

  • [X] US 2004229265 A1 20041118 - LAPIDOT AVIVA [IL], et al
  • [X] WO 2007064954 A2 20070607 - ISIS PHARMACEUTICALS INC [US], et al
  • [X] WO 2008092690 A1 20080807 - EIDGENOESS TECH HOCHSCHULE [CH], et al
  • [X] BERA S ET AL: "Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: Polycationic lipids with potent gram-positive activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 51, no. 19, 9 October 2008 (2008-10-09), pages 6160 - 6164, XP008123388, ISSN: 0022-2623, [retrieved on 20080909], DOI: 10.1021/JM800345U
  • [X] TODA, SOICHIRO ET AL: "Aminoglycoside antibiotics. XV. Chemical conversion of neomycin B to paromomycin I, 6'''-deamino-6'''-hydroxyneomycin B and 6'''-deamino-6'''-hydroxyparomomycin I", JOURNAL OF ANTIBIOTICS , 36(1), 87-91 CODEN: JANTAJ; ISSN: 0021-8820, 1983, XP002711787
  • [X] RASHMI PATHAK ET AL: "Synthesis and Evaluation of Paromomycin Derivatives Modified at C(4')", HELVETICA CHIMICA ACTA, vol. 91, no. 8, 1 August 2008 (2008-08-01), pages 1533 - 1552, XP055076079, ISSN: 0018-019X, DOI: 10.1002/hlca.200890167
  • See references of WO 2011124986A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2011124986 A2 20111013; WO 2011124986 A3 20111215; CA 2791253 A1 20111013; EP 2556079 A2 20130213; EP 2556079 A4 20131009; US 2013157969 A1 20130620; US 8999942 B2 20150407

DOCDB simple family (application)

IB 2011001226 W 20110405; CA 2791253 A 20110405; EP 11765147 A 20110405; US 201113639223 A 20110405