EP 2556082 B1 20170222 - SUBSTITUTED ANDROST-4-ENE DIONES
Title (en)
SUBSTITUTED ANDROST-4-ENE DIONES
Title (de)
SUBSTITUIERTE ANDROST-4-EN-DIONE
Title (fr)
ANDROST-4-ÈNE DIONES SUBSTITUÉES
Publication
Application
Priority
- US 32206210 P 20100408
- US 2011031501 W 20110407
Abstract (en)
[origin: WO2011127232A2] The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, inluding benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.
IPC 8 full level
C07J 1/00 (2006.01); A61K 31/566 (2006.01); A61P 5/00 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 31/565 (2013.01 - EP US); A61K 31/5685 (2013.01 - EP US); A61K 45/06 (2013.01 - US); A61P 5/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07J 1/0011 (2013.01 - EP US); C07J 41/0005 (2013.01 - EP US); C07J 75/00 (2013.01 - US); C07J 51/00 (2013.01 - EP US); C07J 53/001 (2013.01 - EP US)
Citation (examination)
DEBASHIS GHOSH ET AL: "Novel Aromatase Inhibitors by Structure-Guided Design", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 19, 11 October 2012 (2012-10-11), pages 8464 - 8476, XP055164672, ISSN: 0022-2623, DOI: 10.1021/jm300930n
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011127232 A2 20111013; WO 2011127232 A3 20120209; AU 2011237592 A1 20121025; AU 2011237592 B2 20161027; CA 2794565 A1 20111013; CA 2794565 C 20180821; CN 102884072 A 20130116; EP 2556082 A2 20130213; EP 2556082 A4 20140521; EP 2556082 B1 20170222; US 2013157988 A1 20130620; US 2015148321 A1 20150528; US 8969327 B2 20150303
DOCDB simple family (application)
US 2011031501 W 20110407; AU 2011237592 A 20110407; CA 2794565 A 20110407; CN 201180017316 A 20110407; EP 11766695 A 20110407; US 201113635924 A 20110407; US 201514606104 A 20150127