Global Patent Index - EP 2560489 A4

EP 2560489 A4 20140122 - COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF

Title (en)

COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF

Title (de)

ZUSAMMENSETZUNGEN MIT ENZYMSPALTBAREN OPIOID-PRODRUGS UND HEMMER DAFÜR

Title (fr)

COMPOSITIONS COMPRENANT DES PROMÉDICAMENTS OPIACÉS CLIVABLES PAR ENZYME ET LEURS INHIBITEURS

Publication

EP 2560489 A4 20140122 (EN)

Application

EP 10850371 A 20100421

Priority

US 2010031953 W 20100421

Abstract (en)

[origin: WO2011133149A1] The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.

IPC 8 full level

A01N 43/42 (2006.01); A61K 31/44 (2006.01)

CPC (source: EP)

A61K 31/44 (2013.01); A61K 45/06 (2013.01); A61P 25/04 (2017.12)

Citation (search report)

  • [E] WO 2010045599 A1 20100422 - PHARMACOFORE INC [US], et al
  • [Y] WO 2007140272 A2 20071206 - PHARMACOFORE INC [US], et al
  • [Y] WO 2008101187 A2 20080821 - PHARMACOFORE INC [US], et al
  • [Y] PAULETTI GIOVANNI M ET AL: "Esterase-sensitive cyclic prodrugs of peptides: Evaluation of a phenylpropionic acid promoiety in a model hexapeptide", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US, vol. 14, no. 1, 1 January 1997 (1997-01-01), pages 11 - 17, XP002496921, ISSN: 0724-8741, DOI: 10.1023/A:1012091014242
  • [Y] SONG XIAOPING ET AL: "Synthesis of a novel cyclic prodrug of RGD peptidomimetic to improve its cell membrane permeation.", BIOORGANIC CHEMISTRY AUG 2002, vol. 30, no. 4, August 2002 (2002-08-01), pages 285 - 301, XP002717776, ISSN: 0045-2068
  • [Y] KATRAGADDA S ET AL: "Simultaneous modulation of transport and metabolism of acyclovir prodrugs across rabbit cornea: An approach involving enzyme inhibitors", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 320, no. 1-2, 31 August 2006 (2006-08-31), pages 104 - 113, XP027972848, ISSN: 0378-5173, [retrieved on 20060831]
  • See references of WO 2011133149A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

Designated extension state (EPC)

AL BA ME RS

DOCDB simple family (publication)

WO 2011133149 A1 20111027; AU 2010351605 A1 20121122; AU 2010351605 B2 20150129; AU 2010351605 C1 20150806; BR 112012026768 A2 20150929; CA 2795222 A1 20111027; CN 102917589 A 20130206; EP 2560489 A1 20130227; EP 2560489 A4 20140122; IL 222354 A0 20121231; JP 2013525348 A 20130620; RU 2012149438 A 20140527

DOCDB simple family (application)

US 2010031953 W 20100421; AU 2010351605 A 20100421; BR 112012026768 A 20100421; CA 2795222 A 20100421; CN 201080067102 A 20100421; EP 10850371 A 20100421; IL 22235412 A 20121011; JP 2013506120 A 20100421; RU 2012149438 A 20100421