EP 2560490 A1 20130227 - COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF
Title (en)
COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF
Title (de)
ZUSAMMENSETZUNGEN MIT ENZYMSPALTBAREN WIRKSTOFFPRODRUGS UND HEMMER DAFÜR
Title (fr)
COMPOSITIONS COMPRENANT DES PROMÉDICAMENTS CLIVABLES PAR ENZYME DE PRINCIPES ACTIFS ET LEURS INHIBITEURS
Publication
Application
Priority
US 2010031954 W 20100421
Abstract (en)
[origin: WO2011133150A1] The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.
IPC 8 full level
A01N 43/42 (2006.01); A61K 31/44 (2006.01)
CPC (source: EP)
A61K 47/67 (2017.07); B82Y 5/00 (2013.01); C07K 5/06026 (2013.01)
Citation (search report)
See references of WO 2011133150A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
AL BA ME RS
DOCDB simple family (publication)
DOCDB simple family (application)
US 2010031954 W 20100421; EP 10850372 A 20100421