EP 2561352 B1 20160330 - GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF
Title (en)
GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF
Title (de)
MIT DEM ANSPRECHEN AUF STATINE UND HERZ-KREISLAUF-ERKRANKUNGEN ASSOZIIERTE GENETISCHE POLYMORPHISMEN, NACHWEISVERFAHREN DAFÜR UND IHRE VERWENDUNG
Title (fr)
POLYMORPHISMES GÉNÉTIQUES ASSOCIÉS À LA RÉPONSE À LA STATINE ET AUX MALADIES CARDIOVASCULAIRES, PROCÉDÉS DE DÉTECTION ET LEURS UTILISATIONS
Publication
Application
Priority
- US 40597210 P 20101022
- US 33250910 P 20100507
- US 32568910 P 20100419
- US 2011032665 W 20110415
Abstract (en)
[origin: WO2011133418A1] Compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke are provided. For example, nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection are disclosed.
IPC 8 full level
C12Q 1/68 (2006.01); G16B 20/20 (2019.01); G16B 20/30 (2019.01); G16B 20/50 (2019.01); G16B 25/20 (2019.01)
CPC (source: EP US)
A61K 31/22 (2013.01 - EP US); A61K 31/366 (2013.01 - EP US); A61K 31/397 (2013.01 - EP US); A61K 31/40 (2013.01 - EP US); A61K 31/405 (2013.01 - EP US); A61K 31/455 (2013.01 - EP US); A61K 31/505 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); C12Q 1/6883 (2013.01 - EP US); G16B 20/20 (2019.01 - EP US); G16B 20/30 (2019.01 - EP US); G16B 20/50 (2019.01 - EP US); G16B 25/20 (2019.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/156 (2013.01 - EP US); C12Q 2600/172 (2013.01 - EP US); G16B 20/00 (2019.01 - EP US); G16B 25/00 (2019.01 - EP US)
Citation (examination)
DOV SHIFFMAN ET AL: "Genome-Wide Study of Gene Variants Associated with Differential Cardiovascular Event Reduction by Pravastatin Therapy", PLOS ONE, vol. 7, no. 5, E38240, 1 May 2012 (2012-05-01), pages 1 - 10, XP055205072, DOI: 10.1371/journal.pone.0038240
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2011133418 A1 20111027; CA 2796880 A1 20111027; CA 2796880 C 20201201; CA 3060628 A1 20111027; CA 3060628 C 20240430; EP 2561352 A1 20130227; EP 2561352 A4 20130821; EP 2561352 B1 20160330; EP 3056899 A1 20160817; EP 3056899 B1 20180328; EP 3396376 A1 20181031; EP 3396376 B1 20200129; EP 3660508 A1 20200603; EP 3660508 B1 20210818; JP 2013524810 A 20130620; JP 2016029952 A 20160307; JP 2017063795 A 20170406; JP 2018161156 A 20181018; JP 2020096637 A 20200625; JP 2020096638 A 20200625; JP 2022033877 A 20220302; JP 2022033878 A 20220302; JP 5918216 B2 20160518; JP 6157571 B2 20170705; JP 6839779 B2 20210310; JP 7175371 B2 20221118; US 10563263 B2 20200218; US 11827937 B2 20231128; US 2011269735 A1 20111103; US 2014235605 A1 20140821; US 2016108473 A1 20160421; US 2019032136 A1 20190131; US 2020270689 A1 20200827
DOCDB simple family (application)
US 2011032665 W 20110415; CA 2796880 A 20110415; CA 3060628 A 20110415; EP 11772473 A 20110415; EP 16153844 A 20110415; EP 18163929 A 20110415; EP 19207986 A 20110415; JP 2013506194 A 20110415; JP 2015230300 A 20151126; JP 2017000353 A 20170105; JP 2018141168 A 20180727; JP 2020031255 A 20200227; JP 2020031256 A 20200227; JP 2021196089 A 20211202; JP 2021196090 A 20211202; US 201113085955 A 20110413; US 201313833905 A 20130315; US 201514834946 A 20150825; US 201815952792 A 20180413; US 201916728333 A 20191227