Global Patent Index - EP 2569297 A1

EP 2569297 A1 20130320 - SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

Title (en)

SUBSTITUTED N-HETEROCYCLOALKYL BIPYRROLIDINYLPHENYL AMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

Title (de)

SUBSTITUIERTE N-HETEROCYCLOALKYL-BIPYRROLIDINPHENYLAMIDDERIVATE, IHRE ZUBEREITUNG UND THERAPEUTISCHE VERWENDUNG

Title (fr)

DÉRIVÉS DE N-HÉTÉROCYCLOALKYL-BIPYRROLIDINYLPHÉNYLAMIDE SUBSTITUÉS, PRÉPARATION ET UTILISATION THÉRAPEUTIQUE DE CEUX-CI

Publication

EP 2569297 A1 20130320 (EN)

Application

EP 11731175 A 20110510

Priority

  • FR 1061069 A 20101222
  • US 33338710 P 20100511
  • US 2011035842 W 20110510

Abstract (en)

[origin: WO2011143161A1] The present invention discloses and claims a series of substituted N- heterocycloalkyl bipyrrolidinylphenyl amide derivatives of formula (I). (Formula (I)) Wherein R, R1, R2, R3, R4, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives of formula (I) and intermediates therefor.

IPC 8 full level

C07D 401/12 (2006.01); A61K 31/351 (2006.01); A61K 31/4439 (2006.01); A61P 25/00 (2006.01); C07D 405/12 (2006.01)

CPC (source: EP)

A61P 3/04 (2018.01); A61P 25/00 (2018.01); A61P 25/10 (2018.01); A61P 25/14 (2018.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/20 (2018.01); A61P 25/22 (2018.01); A61P 25/24 (2018.01); A61P 25/26 (2018.01); A61P 25/28 (2018.01); A61P 43/00 (2018.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01)

Citation (search report)

See references of WO 2011143161A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2011143161 A1 20111117; AR 081382 A1 20120829; EP 2569297 A1 20130320; JP 2013529198 A 20130718; TW 201206910 A 20120216; US 2013059891 A1 20130307; US 8754095 B2 20140617

DOCDB simple family (application)

US 2011035842 W 20110510; AR P110101613 A 20110510; EP 11731175 A 20110510; JP 2013510225 A 20110510; TW 100116249 A 20110510; US 201213670026 A 20121106