EP 2572707 A2 20130327 - Microparticles with adsorbed polypeptide-containing molecules

Title (en)

Microparticles with adsorbed polypeptide-containing molecules

Title (de)

Mikropartikel mit adsorbierten polypeptidhaltigen Molekülen

Title (fr)

Microparticules avec des molécules contenant un polypeptide adsorbé

Publication

EP 2572707 A2 20130327 (EN)

Application

EP 12178688 A 20030220

Priority

EP 03711136 A 20030220
US 35831502 P 20020220

Abstract (en)

Microparticles with adsorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(±-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 20,000 Daltons to 70,000 Daltons. Preferred polypeptide-containing molecules are bacterial and viral antigens (including HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens).

IPC 8 full level

A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 39/02 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); A61K 39/39 (2006.01); A61K 47/48 (2006.01); A61K 9/00 (2006.01)

CPC (source: EP US)

A61K 9/1647 (2013.01 - EP US); A61K 9/1676 (2013.01 - EP US); A61K 9/1694 (2013.01 - EP US); A61K 39/02 (2013.01 - EP US); A61K 39/095 (2013.01 - EP US); A61K 39/39 (2013.01 - EP US); A61K 47/6927 (2017.07 - EP US); A61P 31/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 31/14 (2017.12 - EP); A61P 31/16 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 31/20 (2017.12 - EP); A61P 37/04 (2017.12 - EP); A61K 2039/55555 (2013.01 - EP US); A61K 2039/6093 (2013.01 - EP US); C12N 2730/10111 (2013.01 - EP US); C12N 2760/16111 (2013.01 - EP US)

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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

DOCDB simple family (publication)

WO 03070909 A2 20030828; WO 03070909 A3 20050331; AU 2003215316 A1 20030909; AU 2003215316 A8 20030909; CA 2476626 A1 20030828; EP 1531796 A2 20050525; EP 1531796 A4 20071219; EP 1531796 B1 20160928; EP 2572707 A2 20130327; EP 2572707 A3 20131106; ES 2607431 T3 20170331; JP 2006507213 A 20060302; JP 2010070555 A 20100402; JP 2013231069 A 20131114; JP 2016006109 A 20160114; JP 4646516 B2 20110309; JP 5832485 B2 20151216; US 2005220883 A1 20051006; US 7501134 B2 20090310

DOCDB simple family (application)

US 0305017 W 20030220; AU 2003215316 A 20030220; CA 2476626 A 20030220; EP 03711136 A 20030220; EP 12178688 A 20030220; ES 03711136 T 20030220; JP 2003569802 A 20030220; JP 2009266874 A 20091124; JP 2013147848 A 20130716; JP 2015162589 A 20150820; US 50525005 A 20050513