EP 2574171 A1 20130403 - REPAIR OF FRAGMENTED DNA AND TREATMENT OF HEAVY METAL INTOXICATION BY INTRAVENOUS INJECTION OF NANO-HYDROXYAPATITE
Title (en)
REPAIR OF FRAGMENTED DNA AND TREATMENT OF HEAVY METAL INTOXICATION BY INTRAVENOUS INJECTION OF NANO-HYDROXYAPATITE
Title (de)
REPARATUR VON FRAGMENTIERTER DNA UND BEHANDLUNG VON SCHWERMETALLVERGIFTUNGEN MITTELS INTRAVENÖSER INJEKTION VON NANO-HYDROXYAPATIT
Title (fr)
RÉPARATION D'ADN FRAGMENTÉ ET TRAITEMENT D'UNE INTOXICATION AUX MÉTAUX LOURDS PAR INJECTION INTRAVEINEUSE DE NANO-HYDROXYAPATITE
Publication
Application
Priority
- EG 2010040557 A 20100407
- EG 2010000019 W 20100414
Abstract (en)
[origin: WO2011124234A1] Synthesis of nano-hydroxyapatite by an organic-inorganic complexion route. Such material was injected intravenously into rats after the exposure of these rats to LD50 of toxic heavy metal. The prepared nano-hydroxyapatite success in repair the fragmented DNA within 48 hours after injection with single dose only without any side effects. Also, heart, liver and thyroid function enzymes were evaluated and the results confirmed the bio-safe usage of this made material. Therefore, the prepared nano-hydroxyapatite can be use safely as a thereby by intravenous injection with suitable doses for different diseases such as cancer, poising and osteoporosis.
IPC 8 full level
A61K 33/42 (2006.01); A61P 39/00 (2006.01)
CPC (source: EP)
A61K 9/0019 (2013.01); A61K 33/42 (2013.01); A61P 39/00 (2017.12)
Citation (search report)
See references of WO 2011124234A1
Citation (examination)
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- JUN HU ET AL: "Effect of hydroxyapatite nanoparticles on the growth and p53/c-Myc protein expression of implanted hepatic VX2 tumor in rabbits by intravenous injection.", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 13, no. 20, 1 May 2007 (2007-05-01), pages 2798 - 2802, XP055097603, ISSN: 1007-9327
- YUAN Y ET AL: "Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 31, no. 4, 1 February 2010 (2010-02-01), pages 730 - 740, XP026762081, ISSN: 0142-9612, [retrieved on 20091202], DOI: 10.1016/J.BIOMATERIALS.2009.09.088
- ALIS YOVANA PATAQUIVA-MATEUS ET AL: "Nanoparticles of hydroxyapatite: preparation, characterization and cellular approach -An Overview", REVISTA MUTIS, 1 January 2013 (2013-01-01), pages 43 - 57, XP055251961
- FERRAZ M P ET AL: "Hydroxyapatite nanoparticles: A reviw of preparation methodologies", JOURNAL OF APPLIED BIOMATERIALS, JOHN WILEY & SONS, INC., NEW YORK, NY, US, vol. 2, 1 January 2004 (2004-01-01), pages 74 - 80, XP002468051, ISSN: 1045-4861
- DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 10 May 2005 (2005-05-10), UOTA MASAFUMI ET AL: "Synthesis of high surface area hydroxyapatite nanoparticles by mixed surfactant-mediated approach.", Database accession no. NLM16032896
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
DOCDB simple family (application)
EG 2010000019 W 20100414; EP 10720528 A 20100414