EP 2576521 A1 20130410 - GADOBUTROL PREPARATION IN A ONE-POT PROCESS BY MEANS OF DMF ACETAL AND N-METHYLIMIDAZOLE
Title (en)
GADOBUTROL PREPARATION IN A ONE-POT PROCESS BY MEANS OF DMF ACETAL AND N-METHYLIMIDAZOLE
Title (de)
GADOBUTROLHERSTELLUNG IM EINTOPFVERFAHREN MITTELS DMF-ACETAL UND N-METHYLIMIDAZOL
Title (fr)
PRODUCTION DE GADOBUTROL DANS UN PROCÉDÉ À UN SEUL RÉACTEUR PAR L'INTERMÉDIAIRE DE DMF ACÉTAL ET DE N-MÉTHYLIMIDAZOL
Publication
Application
Priority
- DE 102010023105 A 20100604
- EP 2011058988 W 20110531
Abstract (en)
[origin: CA2801255A1] A process is described for preparation of the gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl- 1,4,7,10-tetraazacyclododecane "gadobutrol = Gadovist®" in a one-pot process by means of DMF acetal and N-methylimidazole. Gadovist is a gadolinium-containing contrast agent for nuclear spin tomography and has been approved since 2000 in Germany in the indication "contrast amplification in cranial and spinal magnetic resonance tomography".
IPC 8 full level
C07D 257/02 (2006.01)
CPC (source: EP KR US)
C01F 17/00 (2013.01 - KR); C07D 257/02 (2013.01 - EP KR US); C07F 5/00 (2013.01 - US)
Citation (search report)
See references of WO 2011151347A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
DE 102010023105 A1 20111208; AU 2011260310 A1 20130110; BR 112012030902 A2 20150922; CA 2801255 A1 20111208; CN 102933562 A 20130213; EP 2576521 A1 20130410; JP 2013527212 A 20130627; KR 20130089229 A 20130809; MX 2012014161 A 20130227; RU 2012157538 A 20140720; US 2013116429 A1 20130509; WO 2011151347 A1 20111208; ZA 201209037 B 20140226
DOCDB simple family (application)
DE 102010023105 A 20100604; AU 2011260310 A 20110531; BR 112012030902 A 20110531; CA 2801255 A 20110531; CN 201180027353 A 20110531; EP 11724601 A 20110531; EP 2011058988 W 20110531; JP 2013512876 A 20110531; KR 20137000141 A 20110531; MX 2012014161 A 20110531; RU 2012157538 A 20110531; US 201113701914 A 20110531; ZA 201209037 A 20121129