EP 2580184 A2 20130417 - PROCESS FOR PREPARING CRYSTALLINE 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMETHYL)-4-(4-ETHOXYBENZYL)UNDECANEDIOIC ACID AND USE FOR PRODUCTION OF PRIMOVIST®
Title (en)
PROCESS FOR PREPARING CRYSTALLINE 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMETHYL)-4-(4-ETHOXYBENZYL)UNDECANEDIOIC ACID AND USE FOR PRODUCTION OF PRIMOVIST®
Title (de)
VERFAHREN ZUR HERSTELLUNG KRISTALLINER 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMETHYL)-4-(4-ETHOXYBENZYL)-UNDECANDISÄURE UND DIE VERWENDUNG ZUR HERSTELLUNG VON PRIMOVIST®
Title (fr)
PROCÉDÉ DE PRÉPARATION D'ACIDE 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMÉTHYL)-4-(4-ÉTHOXYBENZYL)-UNDÉCANDIOÏQUE CRISTALLIN ET SON UTILISATION POUR LA PRÉPARATION DE PRIMOVIST®
Publication
Application
Priority
- BR PI1002466 A 20100719
- DE 102010023890 A 20100611
- EP 2011059243 W 20110606
Abstract (en)
[origin: WO2011154333A2] The invention relates to a process for preparing crystalline 3,6,9-triaza- 3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula (I) by hydrolysis of di-tert-butyl 3,6,9-triaza-3,6,9-tris(tert- butoxycarbonylmethyl)-4-(4-ethoxybenzyl)undecanedioate of the formula (II) in an aqueous alkali metal hydroxide solution, and to the use of 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula I for preparation of the gadolinium complex of 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid[(Gd-EOB-DTPA) = Primovist®].
IPC 8 full level
C07C 227/42 (2006.01); C07C 227/18 (2006.01); C07C 229/36 (2006.01)
CPC (source: EP KR US)
C07C 227/18 (2013.01 - EP KR US); C07C 227/42 (2013.01 - EP KR US); C07C 229/16 (2013.01 - EP US); C07C 229/26 (2013.01 - US); C07C 229/36 (2013.01 - KR)
C-Set (source: EP US)
Citation (search report)
See references of WO 2011154333A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2011154333 A2 20111215; WO 2011154333 A3 20120216; AU 2011263890 A1 20130124; CA 2801968 A1 20111215; CL 2012003497 A1 20130322; CN 103068790 A 20130424; CO 6650345 A2 20130415; CR 20120627 A 20130313; CU 20120168 A7 20130419; EC SP12012335 A 20121228; EP 2580184 A2 20130417; GT 201200335 A 20140325; IL 223553 A0 20130305; JP 2013531643 A 20130808; KR 20130111513 A 20131010; MA 34304 B1 20130601; MX 2012014490 A 20130207; PE 20130458 A1 20130411; RU 2012157539 A 20140720; SG 186259 A1 20130130; TN 2012000585 A1 20140401; TW 201206876 A 20120216; US 2013158241 A1 20130620; ZA 201300256 B 20140625
DOCDB simple family (application)
EP 2011059243 W 20110606; AU 2011263890 A 20110606; CA 2801968 A 20110606; CL 2012003497 A 20121211; CN 201180038854 A 20110606; CO 12224294 A 20121211; CR 20120627 A 20121211; CU 20120168 A 20121211; EC SP12012335 A 20121211; EP 11724612 A 20110606; GT 201200335 A 20121211; IL 22355312 A 20121211; JP 2013513641 A 20110606; KR 20137000174 A 20110606; MA 35444 A 20121210; MX 2012014490 A 20110606; PE 2012002300 A 20110606; RU 2012157539 A 20110606; SG 2012090684 A 20110606; TN 2012000585 A 20121210; TW 100120431 A 20110610; US 201113703579 A 20110606; ZA 201300256 A 20130110