EP 2584901 A1 20130501 - A PROCESS FOR ETRA VIRINE INTERMEDIATE AND POLYMORPHS OF ETRAVIRINE
Title (en)
A PROCESS FOR ETRA VIRINE INTERMEDIATE AND POLYMORPHS OF ETRAVIRINE
Title (de)
VERFAHREN FÜR ETRAVIRINZWISCHENPRODUKT UND POLYMORPHE VON ETRAVIRIN
Title (fr)
PROCÉDÉ DE PRÉPARATION D'INTERMÉDIAIRE DE L'ÉTRAVIRINE ET DE POLYMORPHES DE L'ÉTRAVIRINE
Publication
Application
Priority
IN 2010000442 W 20100628
Abstract (en)
[origin: WO2012001695A1] 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl- benzonitrile is a key intermediate for the preparation of etravirine. The present invention provides a process for preparation of 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4- pyrimidinyl]oxy]-3,5-dimethylbenzonitrile. The present invention also provides a novel process for the preparation of etravirine crystalline form I. The present invention further provides novel crystalline forms of etravirine, processes for their preparation and pharmaceutical compositions comprising them.
IPC 8 full level
A01N 43/54 (2006.01); A61K 31/505 (2006.01)
CPC (source: EP US)
A61K 31/505 (2013.01 - EP US); C07D 239/47 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2012001695 A1 20120105; CA 2803848 A1 20120105; EP 2584901 A1 20130501; EP 2584901 A4 20131009; US 2013096148 A1 20130418; US 8598341 B2 20131203
DOCDB simple family (application)
IN 2010000442 W 20100628; CA 2803848 A 20100628; EP 10854026 A 20100628; US 201013805920 A 20100628