EP 2588141 A4 20141203 - ANTIBODY FORMULATIONS
Title (en)
ANTIBODY FORMULATIONS
Title (de)
ANTIKÖRPERFORMULIERUNGEN
Title (fr)
FORMULATIONS D'ANTICORPS
Publication
Application
Priority
- US 36120910 P 20100702
- US 2011042838 W 20110701
Abstract (en)
[origin: WO2012003470A2] The present invention relates to formulations comprising sucrose, and methods of making such formulations, wherein the sucrose content promotes the reduction or elimination of the reversible self-association (RSA) tendency of the antibody in the formulation. The present invention also relates to formulations comprising an anti-PDGFR-alpha antibody or antibody fragment. Such antibodies can be used in various methods of treatment. The application further relates to a method of eliminating or reducing the RSA tendency of antibodies in a formulation.
IPC 8 full level
A61K 47/08 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 39/395 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP US)
A61K 9/0019 (2013.01 - EP US); A61K 47/12 (2013.01 - EP US); A61K 47/26 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); C07K 16/00 (2013.01 - EP US); C07K 16/2863 (2013.01 - EP US); A61K 39/39591 (2013.01 - EP US)
Citation (search report)
- [XY] US 6171586 B1 20010109 - LAM XANTHE M [US], et al
- [Y] WO 2006138729 A2 20061228 - IMCLONE SYSTEMS INC [US], et al
- See references of WO 2012003470A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2012003470 A2 20120105; WO 2012003470 A3 20120223; AU 2011274363 A1 20130124; AU 2016201291 A1 20160317; BR 112012033457 A2 20170404; CA 2803998 A1 20120105; CN 103108658 A 20130515; CN 103108658 B 20150819; EP 2588141 A2 20130508; EP 2588141 A4 20141203; JP 2013531679 A 20130808; JP 2016026164 A 20160212; SG 186421 A1 20130130; US 2012009199 A1 20120112; US 8754195 B2 20140617
DOCDB simple family (application)
US 2011042838 W 20110701; AU 2011274363 A 20110701; AU 2016201291 A 20160229; BR 112012033457 A 20110701; CA 2803998 A 20110701; CN 201180042125 A 20110701; EP 11801508 A 20110701; JP 2013518765 A 20110701; JP 2015166305 A 20150826; SG 2012094074 A 20110701; US 201113175522 A 20110701