EP 2603227 A4 20140115 - IMPROVED HEMATOPOIETIC STEM AND PROGENITOR CELL THERAPY
Title (en)
IMPROVED HEMATOPOIETIC STEM AND PROGENITOR CELL THERAPY
Title (de)
VERBESSERTE HÄMATOPOETISCHE STAMM- UND VORLÄUFERZELLTHERAPIE
Title (fr)
TRAITEMENT AMÉLIORÉ UTILISANT DES CELLULES HÉMATOPOÏÉTIQUES SOUCHES ET PROGÉNITRICES
Publication
Application
Priority
- US 37321210 P 20100812
- US 2011047657 W 20110812
Abstract (en)
[origin: WO2012021845A2] The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of modified hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic composition. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
IPC 8 full level
A61K 35/12 (2006.01); A61K 35/44 (2006.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01)
CPC (source: CN EP US)
A61K 35/28 (2013.01 - CN US); A61P 3/00 (2018.01 - EP); A61P 7/00 (2018.01 - EP); A61P 7/04 (2018.01 - EP); A61P 7/06 (2018.01 - EP); A61P 13/02 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C12N 5/0647 (2013.01 - CN EP US); A61K 2035/124 (2013.01 - CN EP US); C12N 2501/02 (2013.01 - CN EP US)
Citation (search report)
- [X] US 2010143317 A1 20100610 - PECORA ANDREW [US], et al
- [Y] WO 2009134532 A2 20091105 - UNIV COLUMBIA [US], et al
- [Y] KYRIAKOU CHARALAMPIA ET AL: "Factors that influence short-term homing of human bone marrow-derived mesenchymal stem cells in a xenogeneic animal model", HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, vol. 93, no. 10, October 2008 (2008-10-01), pages 1457 - 1465, XP009174926
- [Y] SHI MINGXIA ET AL: "Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: Role in homing efficiency in NOD/SCID mice", HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, vol. 92, no. 7, July 2007 (2007-07-01), pages 897 - 904, XP009174928
- [Y] TRISTA E. NORTH ET AL: "Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis", NATURE, vol. 447, no. 7147, 21 June 2007 (2007-06-21), pages 1007 - 1011, XP055002054, ISSN: 0028-0836, DOI: 10.1038/nature05883
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012021845 A2 20120216; WO 2012021845 A3 20120531; AU 2011289245 A1 20130321; AU 2011289245 B2 20150122; BR 112013003366 A2 20200804; CA 2807944 A1 20120216; CA 2807944 C 20200218; CN 103167876 A 20130619; CN 103167876 B 20160831; CN 106214701 A 20161214; CN 106214701 B 20200925; CN 106244547 A 20161221; CN 106244547 B 20210101; CN 112501118 A 20210316; CN 112516167 A 20210319; EP 2603227 A2 20130619; EP 2603227 A4 20140115; EP 2603227 B1 20171004; EP 3278808 A1 20180207; ES 2654994 T3 20180215; JP 2013540105 A 20131031; JP 2016185976 A 20161027; JP 2018104457 A 20180705; JP 2018184448 A 20181122; JP 2020029458 A 20200227; JP 2022009404 A 20220114; JP 2023109761 A 20230808; JP 6047489 B2 20161221; JP 6346917 B2 20180620; JP 6574279 B2 20190911; US 2014030232 A1 20140130; US 2020339953 A1 20201029
DOCDB simple family (application)
US 2011047657 W 20110812; AU 2011289245 A 20110812; BR 112013003366 A 20110812; CA 2807944 A 20110812; CN 201180049420 A 20110812; CN 201610635871 A 20110812; CN 201610638252 A 20110812; CN 202011436734 A 20110812; CN 202011443538 A 20110812; EP 11817137 A 20110812; EP 17188681 A 20110812; ES 11817137 T 20110812; JP 2013524254 A 20110812; JP 2016124416 A 20160623; JP 2018031941 A 20180226; JP 2018139536 A 20180725; JP 2019197587 A 20191030; JP 2021172986 A 20211022; JP 2023071598 A 20230425; US 201113816723 A 20110812; US 202016872061 A 20200511