EP 2603500 B1 20141119 - INHIBITORS OF BRUTON'S TYROSINE KINASE
Title (en)
INHIBITORS OF BRUTON'S TYROSINE KINASE
Title (de)
HEMMER DER BRUTON-TYROSINKINASE
Title (fr)
INHIBITEURS DE TYROSINE KINASE DE BRUTON
Publication
Application
Priority
- US 201161497093 P 20110615
- US 37288710 P 20100812
- EP 2011063657 W 20110809
Abstract (en)
[origin: US2012040949A1] This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
IPC 8 full level
C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 487/10 (2006.01)
CPC (source: EP US)
A61P 11/04 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/14 (2013.01 - EP US); C07D 403/14 (2013.01 - EP US); C07D 405/14 (2013.01 - EP US); C07D 413/14 (2013.01 - EP US); C07D 417/14 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US); C07D 487/08 (2013.01 - EP US); C07D 487/10 (2013.01 - EP US); C07D 491/107 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2012040949 A1 20120216; US 8481540 B2 20130709; AR 082590 A1 20121219; AU 2011288489 A1 20130207; BR 112013003114 A2 20160628; CA 2807634 A1 20120216; CL 2013000391 A1 20130923; CN 103153984 A 20130612; CN 103153984 B 20150422; CO 6620025 A2 20130215; EA 201390207 A1 20130830; EC SP13012437 A 20130328; EP 2603500 A1 20130619; EP 2603500 B1 20141119; ES 2528371 T3 20150209; HK 1186186 A1 20140307; JP 2013533300 A 20130822; JP 5823518 B2 20151125; KR 101546167 B1 20150820; KR 20130038420 A 20130417; MA 34465 B1 20130801; MX 2013001715 A 20130322; PE 20131153 A1 20131005; SG 187747 A1 20130328; US 2013178461 A1 20130711; US 8940741 B2 20150127; WO 2012020008 A1 20120216; ZA 201300705 B 20140625
DOCDB simple family (application)
US 201113207481 A 20110811; AR P110102870 A 20110808; AU 2011288489 A 20110809; BR 112013003114 A 20110809; CA 2807634 A 20110809; CL 2013000391 A 20130208; CN 201180048444 A 20110809; CO 13018558 A 20130131; EA 201390207 A 20110809; EC SP13012437 A 20130208; EP 11746518 A 20110809; EP 2011063657 W 20110809; ES 11746518 T 20110809; HK 13113723 A 20131210; JP 2013523591 A 20110809; KR 20137006162 A 20110809; MA 35658 A 20130212; MX 2013001715 A 20110809; PE 2013000232 A 20110809; SG 2013009246 A 20110809; US 201313781815 A 20130301; ZA 201300705 A 20130125