EP 2603521 A4 20141001 - ANTIBODY MOLECULES TO ONCOGENIC ISOFORMS OF FIBROBLAST GROWTH FACTOR RECEPTOR-2 AND USES THEREOF
Title (en)
ANTIBODY MOLECULES TO ONCOGENIC ISOFORMS OF FIBROBLAST GROWTH FACTOR RECEPTOR-2 AND USES THEREOF
Title (de)
ANTIKÖRPERMOLEKÜLE FÜR ONKOGENE ISOFORMEN DES FIBROBLASTEN-WACHSTUMREZEPTORS 2 UND IHRE VERWENDUNGEN
Title (fr)
MOLÉCULES D'ANTICORPS DIRIGÉES CONTRE DES ISOFORMES ONCOGÈNES DU RÉCEPTEUR 2 DU FACTEUR DE CROISSANCE DES FIBROBLASTES ET LEURS UTILISATIONS
Publication
Application
Priority
- US 37307210 P 20100812
- US 2011047650 W 20110812
Abstract (en)
[origin: WO2012021841A2] Antibody molecules that specifically bind to one or more isoforms expressed and/or associated with oncogenic phenotypes in a hyperproliferative cell (e.g., a cancerous or tumor cell) are disclosed. The isoform-binding antibody molecules can be used to treat, prevent and/or diagnose cancerous conditions and/or disorders. Methods of using the isoform-binding molecules to selectively detect oncogenic isoforms, to reduce the activity and/or induce the killing of a hyperproliferative cell expressing an oncogenic isoform in vitro, ex vivo or in vivo are also disclosed. Diagnostic and/or screening methods and kits for evaluating the function or expression of an oncogenic isoform are also disclosed.
IPC 8 full level
C07K 16/00 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
C07K 16/2863 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01)
Citation (search report)
- [X] WO 2009100105 A2 20090813 - ATTOGEN INC [US], et al
- See references of WO 2012021841A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012021841 A2 20120216; WO 2012021841 A3 20120614; CN 103201287 A 20130710; CN 103201287 B 20160413; EP 2603521 A2 20130619; EP 2603521 A4 20141001
DOCDB simple family (application)
US 2011047650 W 20110812; CN 201180038950 A 20110812; EP 11817134 A 20110812