EP 2626079 A2 20130814 - Conjungated factor VIII molecules
Title (en)
Conjungated factor VIII molecules
Title (de)
Konjugierte Faktor-VIII-Moleküle
Title (fr)
Molécules de facteur VIII conjuguées
Publication
Application
Priority
- US 3200608 P 20080227
- US 4335408 P 20080408
- US 5886908 P 20080604
- EP 09714286 A 20090226
Abstract (en)
The invention concerns B-domain truncated Factor VIII molecules with a modified circulatory half-life, wherein the molecules are covalently conjugated with a hydrophillic polymer via an O-linked oligosaccharide in the truncated B domain, and wherein factor VIII activation results in removal of the covalently conjugated hydrophillic polymer, as well as pharmaceutical compostiions comprising said Factor VIII molecules.
IPC 8 full level
A61K 38/37 (2006.01); A61K 47/48 (2006.01); A61P 7/04 (2006.01); C07K 14/755 (2006.01)
CPC (source: CN EP KR US)
A61K 38/37 (2013.01 - CN EP); A61K 47/26 (2013.01 - US); A61K 47/50 (2017.07 - KR); A61K 47/548 (2017.07 - KR); A61K 47/60 (2017.07 - CN EP US); A61P 7/04 (2017.12 - EP); C07K 14/755 (2013.01 - CN EP); C12N 9/96 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (applicant)
- WO 2008011633 A2 20080124 - NEOSE TECHNOLOGIES INC [US], et al
- US 5932462 A 19990803 - HARRIS MILTON J [US], et al
- US 5629384 A 19970513 - VERONESE FRANCESCO M [IT], et al
- WO 03031464 A2 20030417 - NEOSE TECHNOLOGIES INC [US], et al
- WO 03062290 A1 20030731 - BIOCOMPATIBLES UK LTD [GB], et al
- GRAHAM ET AL., J. GEN. VIROL., vol. 36, 1977, pages 59 - 72
- WAECHTER; BASERGA, PROC.NATL.ACAD.SCI.USA, vol. 79, 1982, pages 1106 - 1110
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- SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 555
- KJALKE, EUR J BIOCHEM, vol. 234, pages 773
- VAN DIEIJEN ET AL., J BIOL GHEM, vol. 256, 1981, pages 3433
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2013137638 A1 20130530; US 8536126 B2 20130917; AU 2009219232 A1 20090903; AU 2009219232 B2 20140227; CA 2715465 A1 20090903; CA 2715465 C 20170321; CN 101965200 A 20110202; CN 101965200 B 20130619; CN 103497246 A 20140108; CN 103497246 B 20160810; CN 103497247 A 20140108; DK 2257311 T3 20140630; EP 2257311 A1 20101208; EP 2257311 B1 20140416; EP 2626079 A2 20130814; EP 2626079 A3 20140305; EP 2626080 A2 20130814; EP 2626080 A3 20140305; ES 2476690 T3 20140715; IL 207188 A0 20101230; IL 207188 A 20160229; JP 2011513327 A 20110428; JP 2014040440 A 20140306; JP 2014221768 A 20141127; JP 5619630 B2 20141105; JP 5927237 B2 20160601; JP 5933503 B2 20160608; KR 101582841 B1 20160111; KR 20110008011 A 20110125; MX 2010009154 A 20100909; PL 2257311 T3 20140930; RU 2010137743 A 20120410; RU 2573587 C2 20160120; TW 200940096 A 20091001; TW I425953 B 20140211; US 2013189239 A1 20130725; US 2014242057 A1 20140828; US 2016222086 A1 20160804; US 9150848 B2 20151006; WO 2009108806 A1 20090903; ZA 201005556 B 20110928
DOCDB simple family (application)
US 201313759261 A 20130205; AU 2009219232 A 20090226; CA 2715465 A 20090226; CN 200980106738 A 20090226; CN 201310180825 A 20090226; CN 201310180846 A 20090226; DK 09714286 T 20090226; EP 09714286 A 20090226; EP 13150933 A 20090226; EP 13150934 A 20090226; ES 09714286 T 20090226; IL 20718810 A 20100725; JP 2010548875 A 20090226; JP 2013200218 A 20130926; JP 2014121288 A 20140612; KR 20107018763 A 20090226; MX 2010009154 A 20090226; PL 09714286 T 20090226; RU 2010137743 A 20090226; TW 98106523 A 20090227; US 2009035339 W 20090226; US 201414272726 A 20140508; US 201514831515 A 20150820; US 59747309 A 20090226; ZA 201005556 A 20100804