EP 2626417 A1 20130814 - Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
Title (en)
Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
Title (de)
Verfahren zur Zellexpansion sowie Verwendungen von damit produzierten Zellen und konditionierten Medien für die Therapie
Title (fr)
Procédés de développement cellulaire et utilisations thérapeutiques des cellules et des milieux conditionnés produits de cette manière
Publication
Application
Priority
- US 78476906 P 20060323
- US 84708806 P 20060926
- EP 11170055 A 20070322
- EP 07713395 A 20070322
Abstract (en)
A method of cell expansion is provided. The method comprising culturing adherent cells from placenta or adipose tissue under three-dimensional culturing conditions, which support cell expansion.
IPC 8 full level
C12N 5/0775 (2010.01); A61K 35/12 (2006.01); C12N 5/073 (2010.01)
CPC (source: EP KR US)
A61K 35/28 (2013.01 - US); A61K 35/50 (2013.01 - US); A61P 1/00 (2018.01 - EP); A61P 1/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 5/14 (2018.01 - EP); A61P 7/00 (2018.01 - EP); A61P 7/06 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 17/02 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 21/00 (2018.01 - EP); A61P 21/04 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C12N 5/0605 (2013.01 - EP US); C12N 5/0653 (2013.01 - US); C12N 5/0663 (2013.01 - EP US); C12N 5/0667 (2013.01 - EP US); C12N 5/0668 (2013.01 - EP KR US); C12N 5/0669 (2013.01 - US); A61K 35/12 (2013.01 - EP US); A61K 2035/122 (2013.01 - EP US); A61K 2035/124 (2013.01 - EP US); C12N 2513/00 (2013.01 - EP US); C12N 2531/00 (2013.01 - EP US); C12N 2533/30 (2013.01 - EP US)
Citation (applicant)
- US 6010696 A 20000104 - CAPLAN ARNOLD I [US], et al
- US 6555374 B1 20030429 - GIMBLE JEFFREY MARTIN [US], et al
- WO 0073421 A2 20001207 - LIFEBANK SERVICES L L C [US], et al
- US 6326198 B1 20011204 - EMERSON STEPHEN G [US], et al
- US 6030836 A 20000229 - THIEDE MARK A [US], et al
- US 6335195 B1 20020101 - RODGERS KATHLEEN E [US], et al
- US 6338942 B2 20020115 - KRAUS MOREY [US], et al
- US 6911201 B1 20050628 - MERCHAV SHOSHANA [IL], et al
- US 6022743 A 20000208 - NAUGHTON GAIL K [US], et al
- US 7045148 B2 20060516 - HARIRI ROBERT J [US]
- US 2002123141 A1 20020905 - HARIRI ROBERT J [US]
- US 2003032179 A1 20030213 - HARIRI ROBERT J [US]
- US 2005011871 A1 20050120 - LAI JIN-SHENG [TW]
- US 6153432 A 20001128 - HALVORSEN YUAN-DI CHANG [US], et al
- US 7078230 B2 20060718 - WILKISON WILLIAM O [US], et al
- US 2006172304 A1 20060803 - FUCHS ELAINE [US], et al
- US 5168085 A 19921201 - ADDIEGO WILLIAM P [US], et al
- US 5266476 A 19931130 - SUSSMAN MARTIN [US], et al
- US 6277151 B1 20010821 - LEE DOSUK D [US], et al
- US 6197575 B1 20010306 - GRIFFITH LINDA G [US], et al
- US 6139578 A 20001031 - LEE DOSUK D [US], et al
- US 6132463 A 20001017 - LEE DOSUK D [US], et al
- US 5902741 A 19990511 - PURCHIO ANTHONY F [US], et al
- US 5629186 A 19970513 - YASUKAWA ROBERT D [US], et al
- US 5486359 A 19960123 - CAPLAN ARNOLD I [US], et al
- US 5942225 A 19990824 - BRUDER SCOTT P [US], et al
- US 5736396 A 19980407 - BRUDER SCOTT P [US], et al
- US 5908784 A 19990601 - JOHNSTONE BRIAN [US], et al
- US 2003219423 A1 20031127 - GAZIT DAN [IL], et al
- US 4666828 A 19870519 - GUSELLA JAMES F [US]
- US 4683202 A 19870728 - MULLIS KARY B [US]
- US 4801531 A 19890131 - FROSSARD PHILIPPE M [US]
- US 5192659 A 19930309 - SIMONS MALCOLM J [AU]
- US 5272057 A 19931221 - SMULSON MARK E [US], et al
- US 3791932 A 19740212 - SCHUURS A, et al
- US 3839153 A 19741001 - SCHUURS A, et al
- US 3850752 A 19741126 - SCHUURS A, et al
- US 3850578 A 19741126 - MCCONNELL H
- US 3853987 A 19741210 - DREYER W
- US 3867517 A 19750218 - LING CHUNG-MEI
- US 3879262 A 19750422 - SCHUURS ANTONIUS HERMANUS WILH, et al
- US 3901654 A 19750826 - GROSS STANLEY J
- US 3935074 A 19760127 - RUBENSTEIN KENNETH EDWARD, et al
- US 3984533 A 19761005 - UZGIRIS EGIDIJUS E
- US 3996345 A 19761207 - ULLMAN EDWIN F, et al
- US 4034074 A 19770705 - MILES LAUGHTON E M
- US 4098876 A 19780704 - PIASIO ROGER N, et al
- US 4879219 A 19891107 - WANDS JACK R [US], et al
- US 5011771 A 19910430 - BELLET DOMINIQUE [FR], et al
- US 5281521 A 19940125 - TROJANOWSKI JOHN Q [US], et al
- ASKENASY ET AL.: "Transplanted hematopoietic cells seed in clusters in recipient bone marrow in vivo", STEM CELLS, vol. 20, 2002, pages 301 - 10
- KERRE ET AL.: "Both CD34+38+ and CD34+38- cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion", J IMMUNOL., vol. 167, 2001, pages 3692 - 8
- JETMORE ET AL.: "Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34(+) cells transplanted into conditioned NOD/SCID recipients", BLOOD, vol. 99, 2002, pages 1585 - 93
- GUREVITCH ET AL.: "Transplantation of allogeneic or xenogeneic bone marrow within the donor stromal microenvironment", TRANSPLANTATION, vol. 68, 1999, pages 1362 - 8
- FAN ET AL.: "Successful allogeneic bone marrow transplantation (BMT) by injection of bone marrow cells via portal vein: stromal cells as BMT-facilitating cells", STEM CELLS, vol. 19, 2001, pages 144 - 50, XP003004926
- ALMEIDA-PORADA ET AL.: "Co-transplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in the circulation and boosts cell levels in bone marrow at later time points after transplantation", BLOOD, vol. 95, pages 3620 - 7, XP002201186
- ZHANG ET AL., STEM CELLS, vol. 22, 2004, pages 1256 - 62
- LIU ET AL., ZHONGHUA XUE YE XUE ZA ZHI, vol. 26, 2005, pages 385 - 8
- KOC ON, J CLIN ONCOL., vol. 18, 2000, pages 307 - 316
- LAZARUS HM, BIOL BLOOD MARROW TRANSPLANT., vol. I, no. 5, May 2005 (2005-05-01), pages 389 - 98
- CHARBORD P.; MOORE, K., ANN. N.Y. ACAD SCI., vol. 1044, 2005, pages 159 - 167
- MAITRA B ET AL., BONE MARROW TRANSPLANT, vol. 33, no. 6, pages 597 - 604
- CHANG CJ; YEN ML; CHEN YC; CHIEN CC; HUANG HI; BAI CH; YEN BL.: "Placenta-derived Multipotent Cells exhibit immunosuppressive properties that are enhanced in the presence of interferon-gamma", STEM CELLS, vol. 24, no. 11, November 2006 (2006-11-01), pages 2466 - 77, XP009082428
- YEN BL; HUANG HI; CHIEN CC; JUI HY; KO BS; YAO M; SHUN CT; YEN ML; LEE MC; CHEN YC: "Isolation of multipotent cells from human term placenta", STEM CELLS, vol. 23, no. 1, 2005, pages 3 - 9, XP002443187, DOI: doi:10.1634/stemcells.2004-0098
- CHANG CJ; YEN ML; CHEN YC; CHIEN CC; HUANG HI; BAI CH; YEN BL: "Placenta-derived multipotent cells exhibit immunosuppressive properties that are enhanced in the presence of interferon-gamma", STEM CELLS, vol. 24, no. L1, November 2006 (2006-11-01), pages 2466 - 77, XP009082428
- YEN BL; HUANG HI; CHIEN CC; JUI HY; KO BS; YAO M; SHUN CT; YEN ML; LEE MC; CHEN YC: "Isolation of Multipotent cells from Human Term Placenta", STEM CELLS, vol. 23, no. 1, 2005, pages 3 - 9, XP002443187, DOI: doi:10.1634/stemcells.2004-0098
- M.J.S. DE GROOT-SWINGS; FRANS H.J. CLAAS; WILLEM E. FIBBE; HUMPHREY H.H.; PIETERNELLA S; IN 'T ANKER; SICCO A. SCHERJON; CARIN KLE: "Placenta Isolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human", SEM CELLS, vol. 22, 2004, pages 1338 - 1345, XP002371702, DOI: doi:10.1634/stemcells.2004-0058
- LI CD ET AL., CELL RES., vol. 15, no. 7, July 2005 (2005-07-01), pages 539 - 47
- ZHANGYI ET AL., CHINESE MEDICAL JOURNAL, vol. 117, no. 6, 2004, pages 882 - 887
- MA T ET AL., BIOTECHNOLOGY PROGRESS. BIOTECHNOL PROG, vol. 15, 1999, pages 715 - 24
- YUBING XIE, TISSUE ENGINEERING, vol. 7, no. 5, 2001, pages 585 - 598
- WENDT, D. ET AL., BIOTECHNOL BIOENG, vol. 84, 2003, pages 205 - 214
- KITAGAWA ET AL., BIOTECHNOLOGY AND BIOENGINEERING, vol. 93, no. 5, 2006, pages 947 - 954
- HOSSEINKHANI, H ET AL., TISSUE ENGINEERING, vol. 11, no. 9-10, 2005, pages 1476 - 1488
- GUAN K. ET AL., NATURE, vol. 440, no. 7088, 27 April 2006 (2006-04-27), pages 1199 - 203
- MARSHALL, CT. ET AL., HISTOL HISTOPATHOL., vol. 21, no. 6, June 2006 (2006-06-01), pages 633 - 43
- GEIJSEN N, NATURE, vol. 427, no. 6970, 8 January 2004 (2004-01-08), pages 148 - 54
- PIETERNELLA ET AL., STEM CELLS, vol. 22, 2004, pages 1338 - 1345
- WILLIAM B. JAKOBY AND IRA H. PASTAN,: "Methods in Enzymology", vol. LVIII, ACADEMIC PRESS, INC., article "Cell Culture", pages: 62 72
- KERRE ET AL., J IMMUNOL., vol. 167, 2001, pages 3692 - 8
- JETMORE ET AL., BLOOD, vol. 99, 2002, pages 1585 - 93
- MAITRA B ET AL., BONE MARROW TRANSPLANT., vol. 33, no. 6, 2004, pages 597 - 604
- ULUDAG, H. ET AL.: "Technology of mammalian cell encapsulation", ADV DRUG DELIV REV., vol. 42, 2000, pages 29 - 64, XP002302229, DOI: doi:10.1016/S0169-409X(00)00053-3
- LU MZ ET AL.: "Cell encapsulation with alginate and alpha- phenoxycinnamylidene-acetylated poly(allylamine", BIOTECHNOL BIOENG., vol. 70, 2000, pages 479 - 83, XP008025769, DOI: doi:10.1002/1097-0290(20001205)70:5<479::AID-BIT1>3.0.CO;2-E
- CHANG TM; PRAKASH S.: "Procedures for microencapsulation of enzymes, cells and genetically engineered microorganisms", MOL BIOTECHNOL., vol. 17, 2001, pages 249 - 60
- LU MZ ET AL.: "A novel cell encapsulation method using photosensitive poly(allylamine alpha-cyanocinnamylideneacetate", J MICROENCAPSUL., vol. 17, 2000, pages 245 - 51
- CHIA, S.M. ET AL.: "Multi-layered microcapsules for cell encapsulation", BIOMATERIALS, vol. 23, 2002, pages 849 - 56, XP004322709, DOI: doi:10.1016/S0142-9612(01)00191-0
- SAMBANIS, A.: "Encapsulated islets in diabetes treatment", DIABETES' TECHNOL. THER., vol. 5, 2003, pages 665 - 8
- CANAPLE L. ET AL.: "Improving cell encapsulation through size control", J BIOMATER SCI POLYM ED., vol. 13, 2002, pages 783 - 96
- WILLIAMS D.: "Small is beautiful: microparticle and nanoparticle technology in medical devices", MED DEVICE TECHNOL., vol. 10, 1999, pages 6 - 9
- DESAI, T.A.: "Microfabrication technology for pancreatic cell encapsulation", EXPERT OPIN BIOL THER., vol. 2, 2002, pages 633 - 46
- "Remington's Pharmaceutical Sciences", MACK PUBLISHING CO.
- FINGL ET AL.: "The Pharmacological Basis of Therapeutics", 1975, pages: L
- SAMBROOK ET AL.: "Molecular Cloning: A laboratory Manual", 1989
- AUSUBEL, R. M.,: "Current Protocols in Molecular Biology", vol. I-III, 1994
- AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1989, JOHN WILEY AND SONS
- PERBAL: "A Practical Guide to Molecular Cloning", 1988, JOHN WILEY & SONS
- WATSON ET AL.: "Recombinant DNA", SCIENTIFIC AMERICAN BOOKS
- BIRREN ET AL.: "Genome Analysis: A Laboratory Manual Series", vol. 1-4, 1998, COLD SPRING HARBOR LABORATORY PRESS
- "Cell Biology: A Laboratory Handbook", vol. I-III, 1994
- COLIGAN J. E.,: "Current Protocols in Immunology", vol. I-III, 1994
- STITES ET AL.: "Basic and Clinical Immunology (8th Edition)", 1994, APPLETON & LANGE
- MISHELL AND SHIIGI: "Selected Methods in Cellular Immunology", 1980, W. H. FREEMAN AND CO.
- GAIT, M. J.,: "Oligonucleotide Synthesis", 1984
- HAMES, B. D., AND HIGGINS S. J.: "Nucleic Acid Hybridization", 1995
- HAMES, B. D., AND HIGGINS S. J.,: "Transcription and Translation", 1984
- FRESHNEY, R. I.,: "Animal Cell Culture", 1986
- "Immobilized Cells and Enzymes", 1986, IRL PRESS
- PERBAL, B.: "A Practical Guide to Molecular Cloning", 1984
- "Methods in Enzymology", vol. 1-317, ACADEMIC PRESS
- "PCR Protocols: A Guide To Methods And Applications", 1990, ACADEMIC PRESS
- MARSHAK ET AL.: "Strategies for Protein Purification and Characterization - A Laboratory Course Manual", 1996, CSHL PRESS
- BEER, I. ET AL., PROTEOMICS, vol. 4, 2004, pages 950 - 60
Citation (search report)
- [AD] WO 0046349 A1 20000810 - TECHNION RES & DEV FOUNDATION [IL], et al
- [XY] LI CHANG DONG ET AL: "Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation.", CELL RESEARCH JUL 2005, vol. 15, no. 7, July 2005 (2005-07-01), pages 539 - 547, XP009080356, ISSN: 1001-0602
- [XY] PUISSANT BÉNÉDICTE ET AL: "Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells.", BRITISH JOURNAL OF HAEMATOLOGY APR 2005, vol. 129, no. 1, April 2005 (2005-04-01), pages 118 - 129, XP002377924, ISSN: 0007-1048
- [YD] LAZARUS H M ET AL: "Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, KLUGE CARDEN JENNINGS PUBLISHING, CHARLOTTESVILLE, VA, US, vol. 11, no. 5, 1 May 2005 (2005-05-01), pages 389 - 398, XP025312128, ISSN: 1083-8791, [retrieved on 20050501], DOI: 10.1016/J.BBMT.2005.02.001
- [YP] BURGER O ET AL: "Mesenchymal stromal cells, grown as high-density 3D culture, promote engraftment of human umbilical cord blood (hUCB) derived CD34+cells in NOD-SCID mice", EXPERIMENTAL HEMATOLOGY; 35TH ANNUAL MEETING OF THE INTERNATIONAL-SOCIETY-FOR-EXPERIMENTAL-HEM ATOLOGY; MINNEAPOLIS, MN, USA; SEPTEMBER 27 -30, 2006, ELSEVIER INC, US, vol. 34, no. 9, Suppl. 1, 1 September 2006 (2006-09-01), pages 38, XP002656152, ISSN: 0301-472X
- [A] YAN LI ET AL: "Effects of three-dimensional scaffolds on cell organization and tissue development", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 6, no. 5, 1 October 2001 (2001-10-01), pages 311 - 325, XP055004175, ISSN: 1226-8372, DOI: 10.1007/BF02932999
- [XY] ZHANG Y ET AL: "COMPARISON OF MESENCHYMAL STEM CELLS FROM HUMAN PLACENTA AND BONE MARROW", CHINESE MEDICAL JOURNAL / ZHONGHUA YIXUE ZAZHI YINGWEN BAN, CHINESE MEDICAL ASSOCIATION, BEIJING, CN, vol. 117, no. 6, 1 June 2004 (2004-06-01), pages 882 - 887, XP009042592, ISSN: 0366-6999
- [A] MOSBEUX C ET AL: "Mesenchymal cells: Metalloproteinases and adhesion on microcarriers", 1 January 2006, ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, SPRINGER, NL, PAGE(S) 1 - 7, ISBN: 978-1-4020-4312-3, XP008121294
- [A] Q F WU ET AL: "Cultivation of human mesenchymal stem cells on macroporous CultiSpher G microcarriers", ZHONGGUO SHI YAN XUE YE XUE ZA ZHI, vol. 11, no. 1, 1 January 2003 (2003-01-01), pages 15 - 21, XP055042840
- [X] YANEZ R M ET AL: "IN VITRO AND IN VIVO IMMUNOMODULATORY EFFECTS OF MESENCHYMAL STEM CELLS FROM ADIPOSE TISSUE", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 106, no. 11. PART 01, 13 December 2005 (2005-12-13), pages 866A, XP009065433, ISSN: 0006-4971
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR MK RS
DOCDB simple family (publication)
WO 2007108003 A2 20070927; WO 2007108003 A3 20090212; AU 2007228341 A1 20070927; AU 2007228341 B2 20131017; BR PI0709349 A2 20110712; CA 2646384 A1 20070927; CA 2646384 C 20200324; CN 105296415 A 20160203; DK 2366775 T3 20150615; DK 2626417 T3 20151102; EP 2010647 A2 20090107; EP 2010647 A4 20100519; EP 2366775 A1 20110921; EP 2366775 B1 20150422; EP 2548951 A1 20130123; EP 2548951 B1 20160504; EP 2626417 A1 20130814; EP 2626417 B1 20150902; EP 3091071 A1 20161109; EP 3091071 B1 20190703; ES 2537641 T3 20150610; ES 2549528 T3 20151029; ES 2572214 T3 20160530; HK 1136846 A1 20100709; HK 1160174 A1 20120810; HK 1177759 A1 20130830; HK 1187950 A1 20140417; HK 1217513 A1 20170113; HR P20160538 T1 20160715; HU E028796 T2 20170130; IL 236213 A 20170928; JP 2009531059 A 20090903; JP 2011219486 A 20111104; JP 2014088408 A 20140515; JP 5733894 B2 20150610; JP 5766041 B2 20150819; JP 5941454 B2 20160629; KR 101490449 B1 20150205; KR 101557256 B1 20151002; KR 20080110831 A 20081219; KR 20140136045 A 20141127; MX 2008012085 A 20090122; PL 2366775 T3 20150831; PL 2548951 T3 20160831; PT 2366775 E 20150720; PT 2548951 E 20160614; PT 2626417 E 20151116; RU 2008141894 A 20100510; RU 2433177 C2 20111110; SG 170761 A1 20110530; SI 2548951 T1 20160729; US 2011129447 A1 20110602; US 2016022738 A1 20160128
DOCDB simple family (application)
IL 2007000380 W 20070322; AU 2007228341 A 20070322; BR PI0709349 A 20070322; CA 2646384 A 20070322; CN 201510738761 A 20070322; DK 11170055 T 20070322; DK 13164303 T 20070322; EP 07713395 A 20070322; EP 11170055 A 20070322; EP 12189046 A 20070322; EP 13164303 A 20070322; EP 16157193 A 20070322; ES 11170055 T 20070322; ES 12189046 T 20070322; ES 13164303 T 20070322; HK 10103472 A 20100408; HK 12100543 A 20120117; HK 13104666 A 20120117; HK 14100827 A 20120117; HK 16105449 A 20160512; HR P20160538 T 20160519; HU E12189046 A 20070322; IL 23621314 A 20141211; JP 2009502327 A 20070322; JP 2011133774 A 20110616; JP 2013263148 A 20131220; KR 20087025460 A 20070322; KR 20147029038 A 20070322; MX 2008012085 A 20070322; PL 11170055 T 20070322; PL 12189046 T 20070322; PT 07164303 T 20070322; PT 11170055 T 20070322; PT 12189046 T 20070322; RU 2008141894 A 20070322; SG 2011020898 A 20070322; SI 200731782 A 20070322; US 201514873092 A 20151001; US 22547807 A 20070322