EP 2633075 A1 20130904 - CAPTURE OF METHYLATED RNA AND/OR DNA SEQUENCES BY SPECIFIC PROBES
Title (en)
CAPTURE OF METHYLATED RNA AND/OR DNA SEQUENCES BY SPECIFIC PROBES
Title (de)
ERFASSUNG VON METHYLIERTEN RNA- UND/ODER DNA-SEQUENZEN ANHAND SPEZIFISCHER SONDEN
Title (fr)
CAPTURE DE SÉQUENCES D'ARN ET/OU D'ADN MÉTHYLÉ(S) PAR DES SONDES SPÉCIFIQUES
Publication
Application
Priority
- US 40719110 P 20101027
- DK PA201070456 A 20101027
- DK 2011000121 W 20111027
Abstract (en)
[origin: WO2012055409A1] The present invention relates to a technology for specific capture of methylated target DNA and/or RNA by a complementary probe comprising one or more intercalator molecules. The method further involves removal of cytosine residues which are not methylated from the target DNA and/or RNA prior to interaction with the complementary probe. This results in generation of one or more abasic sites which can interact with and/or into where the intercalator molecule can be inserted.
IPC 8 full level
C12Q 1/68 (2006.01)
CPC (source: EP)
C12Q 1/6827 (2013.01)
Citation (search report)
See references of WO 2012055409A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
DOCDB simple family (application)
DK 2011000121 W 20111027; EP 11784930 A 20111027