EP 2633866 A2 20130904 - Combination therapy

Title (en)

Combination therapy

Title (de)

Kombinationstherapie

Title (fr)

Thérapie combinée

Publication

EP 2633866 A2 20130904 (EN)

Application

EP 13152434 A 20041008

Priority

DK PA200301529 A 20031017
US 51342203 P 20031022
DK PA200400707 A 20040504
US 56956604 P 20040510
EP 04762902 A 20041008

Abstract (en)

There is provided an antibody and an IL-21 polypeptide for use in treating cancer, wherein said antibody is selected from: (i) HuMax-CD20, alemtuzumab, and Zamyl; (ii) an antibody against tissue factor, laminin-5, EGF receptor, VEGF receptor, PDGF receptor, HER-2/neu, prostate-specific antigen (PSA), prostate stem cell antigen (PSCA), carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), tumor-associated calcium signal transducer antigen (KSA), or VEGF; (iii) an antibody that activates a TRAIL receptor; or (iii) a monoclonal antibody against CTLA-4, leukocyte immunoglobulin-like receptor 1 (LIR), CD94, or NKG2A.

IPC 8 full level

A61K 38/20 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP US)

A61K 31/655 (2013.01 - EP US); A61K 38/20 (2013.01 - EP US); A61K 39/39533 (2013.01 - US); A61K 39/3955 (2013.01 - US); A61K 39/39558 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP)

Citation (applicant)

WO 0053761 A2 20000914 - ZYMOGENETICS INC [US]
WO 0053761 A2 20000914 - ZYMOGENETICS INC [US]
US 5223409 A 19930629 - LADNER ROBERT C [US], et al
WO 9206204 A1 19920416 - IXSYS INC [US]
US 5155027 A 19921013 - SLEDZIEWSKI ANDRZEJ Z [US], et al
US 5567584 A 19961022 - SLEDZIEWSKI ANDRZEJ Z [US], et al
DK 2004000531 W 20040809
DK 2004000625 W 20040917
WO 9013540 A1 19901115 - ENZON INC [US]
US 5932462 A 19990803 - HARRIS MILTON J [US], et al
US 5643575 A 19970701 - MARTINEZ ANTHONY [US], et al
US 5824778 A 19981020 - ISHIKAWA RIKA [JP], et al
US 5476653 A 19951219 - PITT COLIN G [US], et al
WO 9732607 A2 19970912 - AMGEN BOULDER INC [US], et al
EP 0229108 A1 19870722 - CETUS CORP [US]
EP 0402378 A1 19901219 - CETUS CORP [US]
US 4902502 A 19900220 - NITECKI DANUTE E [US], et al
US 5281698 A 19940125 - NITECKI DANUTE E [US]
US 5122614 A 19920616 - ZALIPSKY SHMUEL [US]
US 5219564 A 19930615 - ZALIPSKY SAMUEL [US], et al
WO 9216555 A1 19921001 - ENZON INC [US]
WO 9404193 A1 19940303 - ENZON INC [US]
WO 9414758 A1 19940707 - ENZON INC [US]
WO 9417039 A1 19940804 - ENZON INC [US]
WO 9418247 A1 19940818 - ENZON INC [US]
WO 9428024 A1 19941208 - ENZON INC [US]
WO 9500162 A1 19950105 - ENZON INC [US]
WO 9511924 A1 19950504 - ENZON INC [US]
WO 9513090 A1 19950518 - ENZON INC [US]
WO 9533490 A1 19951214 - ENZON INC [US]
WO 9600080 A1 19960104 - ENZON INC [US]
WO 9718832 A1 19970529 - ENZON INC [US]
WO 9841562 A1 19980924 - ENZON INC [US]
WO 9848837 A1 19981105 - ENZON INC [US]
WO 9932134 A1 19990701 - ENZON INC [US]
WO 9932139 A1 19990701 - ENZON INC [US]
WO 9932140 A1 19990701 - ENZON INC [US]
WO 9640791 A1 19961219 - NOVO NORDISK AS [DK], et al
WO 9832466 A1 19980730 - POLYMASC PHARMACEUTICALS PLC [GB], et al
WO 9506058 A1 19950302 - ROYAL FREE HOSP SCHOOL MED [GB], et al
EP 0439508 A1 19910807 - ROYAL FREE HOSP SCHOOL MED [GB]
WO 9703106 A1 19970130 - SHEARWATER POLYMERS INC [US], et al
WO 9621469 A1 19960718 - SHEARWATER POLYMERS INC [US], et al
WO 9513312 A1 19950518 - SHEARWATER POLYMERS INC [US], et al
EP 0921131 A1 19990609 - KYOWA HAKKO KOGYO KK [JP]
US 5736625 A 19980407 - CALLSTROM MATTHEW R [US], et al
WO 9805363 A2 19980212 - ORTHO PHARMA CORP [US]
EP 0809996 A2 19971203 - HOFFMANN LA ROCHE [CH]
US 5629384 A 19970513 - VERONESE FRANCESCO M [IT], et al
WO 9641813 A2 19961227 - OFFORD ROBIN E [CH], et al
WO 9607670 A1 19960314 - SURFACE ENG TECH [US]
US 5473034 A 19951205 - YASUI MITSUO [JP], et al
US 5516673 A 19960514 - MARGEL SHLOMO [IL], et al
EP 0605963 A2 19940713 - ORTHO PHARMA CORP [US]
US 5382657 A 19950117 - KARASIEWICZ ROBERT [US], et al
EP 0510356 A1 19921028 - HOFFMANN LA ROCHE [CH]
EP 0400472 A2 19901205 - SUMITOMO PHARMA [JP], et al
EP 0183503 A2 19860604 - BEECHAM GROUP PLC [GB]
EP 0154316 A2 19850911 - TAKEDA CHEMICAL INDUSTRIES LTD [JP]
US 5985265 A 19991116 - KINSTLER OLAF B [US], et al
WO 9955377 A2 19991104 - APPLIED RESEARCH SYSTEMS [NL], et al
WO 2004055168 A2 20040701 - ZYMOGENETICS INC [US]
US 5037743 A 19910806 - WELCH SUSAN K [US], et al
US 5143830 A 19920901 - HOLLAND IAN B [GB], et al
US 4356108 A 19821026 - SCHWAB GERHART, et al
US 4166452 A 19790904 - GENERALES CONSTANTINE D J JR [US]
US 4265874 A 19810505 - BONSEN PIETER, et al
KELSO, A., IM- MUN. CELL BIOL., vol. 76, 1998, pages 300 - 317
SAMBROOK; FRITSCH; MANIATIS: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK ET AL.: "DNA Cloning: A Practical Approach", vol. I-II, 1989
"Oligonucleotide Synthesis", 1984
"Nucleic Acid Hybridization", 1985
"Transcription And Translation", 1984
"Animal Cell Culture", 1986
"Immobilized Cells And Enzymes", 1986, IRL PRESS
B. PERBAL: "A Practical Guide To Molecular Cloning", 1984
"Remington's Pharmaceutical Sciences", 1996, MACK PUBLISHING CO.
ALT- SCHUL ET AL., BULL. MATH. BIO., vol. 48, 1986, pages 603 - 616
HENIKOFF; HENIKOFF, PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 10915 - 10919
A, NILSSON ET AL., EMBO J., vol. 4, 1985, pages 1075
NILSSON ET AL., METHODS ENZYMOL., vol. 198, 1991, pages 3
S TRANSFERASE; SMITH; JOHNSON, GENE, vol. 67, 1988, pages 31
FORD ET AL., PROTEIN EXPRESSION AND PURIFICATION, vol. 2, 1991, pages 95 - 107
CUN- NINGHAM; WELLS, SCIENCE, vol. 244, 1989, pages 1081 - 1085
BASS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 4498 - 4502
REIDHAAR-OLSON; SAUER, SCIENCE, vol. 241, 1988, pages 53 - 57
BOWIE; SAUER, PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 2152 - 2156
LOWMAN ET AL., BIOCHEM., vol. 30, 1991, pages 10832 - 10837
DERBYSHIRE ET AL., GENE, vol. 46, 1986, pages 145
NER ET AL., DNA, vol. 7, 1988, pages 127
TUAN ET AL., CONNECTIVE TISSUE RESEARCH, vol. 34, 1996, pages 1 - 9
R. F. TAYLOR: "Protein immobilisation. Fundamental and applications", 1991, MARCEL DEKKER
S. S. WONG: "Chemistry of Protein Conjugation and Crosslinking", 1992, CRC PRESS
G. T. HER- MANSON ET AL.: "Immobilized Affinity Ligand Techniques", 1993, ACADEMIC PRESS
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
W.R. PEARSON; D.J. LIPMAN: "Improved Tools for Biological Sequence Analysis", PNAS, vol. 85, 1988, pages 2444 - 2448
W.R. PEARSON: "Rapid and Sensitive Sequence Comparison with FASTP and FASTA", METHODS IN ENZYMOLOGY, vol. 183, 1990, pages 63 - 98, XP000670614, DOI: doi:10.1016/0076-6879(90)83007-V
PU ET AL., J BIOL CHEM, vol. 278, 2003, pages 46877
FISCHER; GIANELLA-BORRADORI, EXP OP INVEST DRUGS, vol. 12, 2003, pages 955 - 970
DAMM ET AL., EMBO J, vol. 20, 2001, pages 6958 - 6968
TAUCHI ET AL., ONCOGENE, vol. 22, 2003, pages 5338 - 5347
IGNEY; KRAMMER, NATURE REV. CANCER, vol. 2, 2002, pages 277 - 288
MAKIN; DIVE, TRENDS MOL MED, vol. 9, 2003, pages 2519
SMYTH ET AL., IMMUNITY, vol. 18, 2003, pages 1 - 6
PANARETAKIS ET AL., ONCOGENE, vol. 22, 2003, pages 4543 - 4556
MARX, SCIENCE, vol. 301, 2003, pages 452 - 454
PHAN ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 100, 2003, pages 8372
COUSSENS ET AL., SCIENCE, vol. 295, 2002, pages 2387 - 2392
"Practice of Pharmacy", 1995, MACK PUBLISHING CO.
"Remington: The Science and Practice of Pharmacy", 1995
WILLIAMS; POLLI, J. PARENTERAL SCI. TECHNOL., vol. 38, 1984, pages 48 - 59
MASTERS: "Spray-Drying Handbook", 1991, LONGMAN SCIENTIFIC AND TECHNICAL, pages: 491 - 676
BROADHEAD ET AL., DRUG DEVEL. IND. PHARM., vol. 18, 1992, pages 1169 - 1206
MUMENTHALER ET AL., PHARM. RES., vol. 11, 1994, pages 12 - 20
CARPENTER; CROWE, CRYOBIOLOGY, vol. 25, 1988, pages 459 - 470
ROSER, BIOPHARM., vol. 4, 1991, pages 47 - 53
"Pharmaceutical Controlled Release", 2000, MAR CEL DEKKER
"Protein Formulation and Delivery", vol. 99, 2000, MARCEL DEKKER, article "Drug and the Pharmaceutical Sciences"
AHEM. T.J.; MAN- NING M.C.: "Stability of Protein Pharmaceuticals", 1992, PLENUM PRESS
GOLAY ET AL., HAEMATOLOGICA, vol. 88, 2003, pages 1002 - 1012
LIU ET AL., CANCER LMMUN, vol. 2, no. 13, 2002
WATANABE ET AL., BREAST CANCER RES TREAT, vol. 53, 1999, pages 199 - 207
FLIEGER, J LMMUNOTHER, vol. 23, 2000, pages 480 - 486
FLIEGER ET AL., J IMMUNOL METHODS, vol. 180, no. 1-13, 1995
FLIEGER ET AL., HYBRIDOMA, vol. 18, 1999, pages 63 - 68
AKEWANLOP ET AL., CANCER RES, vol. 61, 2001, pages 4061 - 4065
ZHANG ET AL., BLOOD, vol. 102, 2003, pages 284 - 288
FLAVELL, CANCER RES, vol. 58, 1998, pages 5787 - 5794
PALUMBO ET AL., CANCER RES., vol. 62, 2002, pages 6966 - 6972
BOVE ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 291, 2002, pages 1001 - 1005
WIGGINTON ET AL., J IMMUNOL, vol. 169, 2002, pages 4467 - 4474
AMIRKHOSRAVI ET AL., THROMB.HAEMOST., vol. 87, 2002, pages 930 - 936
HOSAKA ET AL., CANCER LEFT, vol. 16, no. 1, 2000, pages 231 - 240
MAINI ET AL., IN VIVO, vol. 17, 2003, pages 119 - 123
MURPHY ET AL., J IMMUNOL, vol. 170, 2003, pages 2727 - 2733

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

US 2007031374 A1 20070208; EP 2633866 A2 20130904; EP 2633866 A3 20131218; EP 2641611 A2 20130925; EP 2641611 A3 20131218; ES 2428358 T3 20131107; US 2008206192 A1 20080828; US 2010135901 A1 20100603; US 2013071351 A1 20130321

DOCDB simple family (application)

US 40473306 A 20060414; EP 13152056 A 20041008; EP 13152434 A 20041008; ES 04762902 T 20041008; US 11245208 A 20080430; US 201213608542 A 20120910; US 63710909 A 20091214