Global Patent Index - EP 2635300 A4

EP 2635300 A4 20140402 - DOCK-AND-LOCK (DNL) CONSTRUCTS FOR HUMAN IMMUNODEFICIENCY VIRUS (HIV) THERAPY

Title (en)

DOCK-AND-LOCK (DNL) CONSTRUCTS FOR HUMAN IMMUNODEFICIENCY VIRUS (HIV) THERAPY

Title (de)

DOCK-AND-LOCK (DNL)-KONSTRUKTE FÜR EINE THERAPIE GEGEN DEN HUMANEN IMMUNSCHWÄCHEVIRUS (HIV)

Title (fr)

PRODUITS DE RECOMBINAISON DOCK-AND-LOCK (DNL) POUR THÉRAPIE CONTRE LE VIRUS D'IMMUNODÉFICIENCE HUMAINE (VIH)

Publication

EP 2635300 A4 20140402 (EN)

Application

EP 11838781 A 20111103

Priority

  • US 201161487956 P 20110519
  • US 201113036820 A 20110228
  • US 201113021302 A 20110204
  • US 96893610 A 20101215
  • US 94953610 A 20101118
  • US 41459210 P 20101117
  • US 40974010 P 20101103
  • US 2011059056 W 20111103

Abstract (en)

[origin: WO2012061548A1] The present invention concerns methods and compositions for treatment of HIV infection in a subject, utilizing a DNL complex comprising at least one anti-HIV therapeutic agent, attached to an antibody, antibody fragment or PEG. In a preferred embodiment, the antibody or fragment binds to an antigen selected from gp120, gp41, CD4 and CCR5. In a more preferred embodiment the antibody is P4/D10 or 2G12, although other anti-HIV antibodies are known and may be utilized. In a most preferred embodiment, the anti-HIV therapeutic agent is a fusion inhibitor, such as T20, T61, T651, T1249, T2635, CP32M or T-1444, although other anti-HIV therapeutic agents are known and may be utilized. The DNL complex may be administered alone or may be co-administered with one or more additional anti-HIV therapeutic agents.

IPC 8 full level

A61K 47/48 (2006.01); A61K 38/21 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/46 (2006.01)

CPC (source: EP)

A61K 47/6803 (2017.08); A61K 47/6807 (2017.08); A61K 47/6809 (2017.08); A61K 47/6811 (2017.08); A61K 47/6841 (2017.08); A61P 35/00 (2018.01); A61P 37/00 (2018.01); C07K 16/00 (2013.01); C07K 2317/30 (2013.01); C07K 2317/90 (2013.01); C07K 2319/01 (2013.01); C07K 2319/73 (2013.01)

Citation (search report)

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2012061548 A1 20120510; AU 2011323354 A1 20130321; AU 2011323354 B2 20140731; CA 2812442 A1 20120510; CN 103328001 A 20130925; CN 103328001 B 20170215; EP 2635300 A1 20130911; EP 2635300 A4 20140402

DOCDB simple family (application)

US 2011059056 W 20111103; AU 2011323354 A 20111103; CA 2812442 A 20111103; CN 201180051294 A 20111103; EP 11838781 A 20111103