EP 2636675 A4 20140312 - DIPHOSPHONATE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF
Title (en)
DIPHOSPHONATE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF
Title (de)
DIPHOSPHONATVERBINDUNGEN SOWIE VERFAHREN ZU IHRER HERSTELLUNG UND ANWENDUNG
Title (fr)
COMPOSÉS DE DIPHOSPHONATE ET PROCÉDÉ DE PRÉPARATION ET D'UTILISATION DE CEUX-CI
Publication
Application
Priority
- CN 201010529957 A 20101103
- CN 2011078808 W 20110824
Abstract (en)
[origin: EP2636675A1] The present invention relates to a new diphosphonate compound, and the method to prepare the above new diphosphonate compound. The new diphosphonate compound provided in this present invention exhibits an activity in inhibiting osteoclast equivalent to alendronate sodium, and a higer activity in affecting the proliferation of osteoplast than the positive control compounds, but the positive control exhibits a weaker effect on osteoblast proliferation. In experimental examples, an administration schedule for the diphosphonate compound of the present invention is provided.
IPC 8 full level
A61K 31/675 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); C07F 9/40 (2006.01); C07F 9/547 (2006.01); C07F 9/6541 (2006.01)
CPC (source: EP US)
A61P 19/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); C07F 9/4031 (2013.01 - EP US); C07F 9/5475 (2013.01 - EP US); C07F 9/6541 (2013.01 - EP US)
Citation (search report)
- [A] JEAN-PHILIPPE GOURVES: "Synthesis of 3,4-Dihydro-2H-pyrido[1,2-b]isoindol-1-one and 3,4-Dihydro-2H-pyrido[1,2-b]pyrrolidin-1-one Functionalized at the C-6 Position by an Intramolecular Horner-Wadsworth-Emmons Reaction", EUR. J. ORG. CHEM., 1 January 1999 (1999-01-01), pages 3489 - 3493., XP055099003, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/store/10.1002/(SICI)1099-0690(199912)1999:12<3489::AID-EJOC3489>3.0.CO;2-F/asset/3489_ftp.pdf?v=1&t=hr094zu8&s=6f70b65497496e4f73b6c6c0b3b3268248a17442> [retrieved on 20140129]
- See references of WO 2012058976A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 2636675 A1 20130911; EP 2636675 A4 20140312; EP 2636675 B1 20160518; CN 102453050 A 20120516; CN 102453050 B 20150107; JP 2013542946 A 20131128; JP 5792314 B2 20151007; US 2013211097 A1 20130815; US 9045506 B2 20150602; WO 2012058976 A1 20120510
DOCDB simple family (application)
EP 11837502 A 20110824; CN 201010529957 A 20101103; CN 2011078808 W 20110824; JP 2013536987 A 20110824; US 201113880972 A 20110824