EP 2637652 A2 20130918 - OSTEOCLAST ACTIVITY
Title (en)
OSTEOCLAST ACTIVITY
Title (de)
OSTEOKLASTENAKTIVITÄT
Title (fr)
ACTIVITÉ DES OSTÉOCLASTES
Publication
Application
Priority
- GB 201105580 A 20110401
- GB 201105579 A 20110401
- GB 201105578 A 20110401
- US 45893010 P 20101202
- GB 201020377 A 20101201
- GB 201019882 A 20101123
- GB 201019013 A 20101110
- BE 2011000064 W 20111110
Abstract (en)
[origin: WO2012061907A2] The invention relates to medicaments and novel methods of treating metabolic bone diseases, and more particularly for treating or preventing Critical Illness Related Metabolic Bone Disease or of critical illness induced Osteopenia [ICD-10 M85.8, ICD-9 733.90, DiseasesDB 29870 or MeSH D001851] secondary to ICU Admission by sufficient autophagy inducing compound to inhibit or suppressing critical illness [MeSH Descriptor: C23.550.291.625] enhanced osteoclastogenesis or increased osteoclast differentiation. The disclosed therapeutic methods include administering of a autophagy activating compound to a mammal to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) maintain bone mass and/or bone quality or (5) inhibit bone resorption in particularly by inhibiting or reducing a process by which osteoclasts break down bone and release the minerals resulting in a transfer of calcium from bone fluid to the blood. The invention also provides methods for administering the autophagy activating compound to treat a bone disorder of hyperresorption of bone and/or enhanced activation of osteoclasts.
IPC 8 full level
A61K 31/13 (2006.01); A61K 31/436 (2006.01); A61K 31/5415 (2006.01); A61P 19/00 (2006.01)
CPC (source: EP US)
A61K 31/13 (2013.01 - EP US); A61K 31/132 (2013.01 - US); A61K 31/436 (2013.01 - EP US); A61K 31/5415 (2013.01 - EP US); A61K 45/06 (2013.01 - US); A61P 19/00 (2017.12 - EP)
Citation (search report)
See references of WO 2012061907A2
Citation (examination)
- OKUI TATSUO ET AL: "Antitumor Effect of Temsirolimus against Oral Squamous Cell Carcinoma Associated with Bone Destruction", MOLECULAR CANCER THERAPEUTICS, vol. 9, no. 11, 21 September 2010 (2010-09-21), pages 2960 - 2969, ISSN: 1535-7163
- MICHAEL H ET AL: "Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro", BRITISH JOURNAL OF PHARMACOLOGY, vol. 151, no. 3, June 2007 (2007-06-01), pages 384 - 395, ISSN: 0007-1188
- GANGAR SUBHASH CHANDER ET AL: "Silibinin inhibits advanced human prostate carcinoma-induced osteoclastogenesis", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 51, April 2010 (2010-04-01), & 101ST ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH; WASHINGTON, DC, USA; APRIL 17 -21, 2010, pages 1374, ISSN: 0197-016X
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012061907 A2 20120518; WO 2012061907 A3 20120816; EP 2637652 A2 20130918; US 2014066439 A1 20140306
DOCDB simple family (application)
BE 2011000064 W 20111110; EP 11817502 A 20111110; US 201113884913 A 20111110