Global Patent Index - EP 2637670 B1

EP 2637670 B1 20170308 - PREVENTION OF ADVERSE EFFECTS CAUSED BY CD3 SPECIFIC BINDING DOMAINS

Title (en)

PREVENTION OF ADVERSE EFFECTS CAUSED BY CD3 SPECIFIC BINDING DOMAINS

Title (de)

VERMEIDUNG UNERWÜNSCHTER WIRKUNGEN DURCH CD3-SPEZIFISCHE BINDUNGSDOMÄNEN

Title (fr)

PRÉVENTION DES EFFETS SECONDAIRES PROVOQUÉS PAR DES DOMAINES DE LIAISON SPÉCIFIQUES DE CD3

Publication

EP 2637670 B1 20170308 (EN)

Application

EP 11788077 A 20111027

Priority

  • US 41222910 P 20101110
  • EP 2011068862 W 20111027

Abstract (en)

[origin: WO2012062596A1] The present invention relates to a glucocorticoid (GC) for use in the amelioration, treatment or prophylaxis of neurological/psychiatric adverse events caused by a CD3 binding domain. Kits comprising a GC, a CD3 binding domain and instructions for use which indicate that the GC is to be employed for the treatment amelioration and/or prophylaxis of neurological adverse events caused by said CD3 binding domain, are also disclosed.

IPC 8 full level

A61K 31/573 (2006.01); A61K 39/395 (2006.01)

CPC (source: EP IL KR US)

A61K 31/573 (2013.01 - EP IL KR US); A61K 39/395 (2013.01 - KR); A61K 39/3955 (2013.01 - EP IL US); A61K 39/39558 (2013.01 - EP IL US); A61P 25/00 (2018.01 - EP); A61P 25/08 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 16/28 (2013.01 - KR); C07K 16/2803 (2013.01 - EP IL US); C07K 16/2809 (2013.01 - EP IL US); A61K 2039/505 (2013.01 - EP IL US); A61K 2300/00 (2013.01 - EP IL US); C07K 2317/31 (2013.01 - EP IL US)

C-Set (source: EP US)

A61K 31/573 + A61K 2300/00

Citation (opposition)

Opponent : F. Hoffmann-La Roche AG

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  • HOFFMANN ET AL.: "Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct", INTERNATIONAL JOURNAL OF CANCER, vol. 115, no. 1, 20 May 2005 (2005-05-20), pages 98 - 104, XP002335808
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Opponent : Lindis Biotech GmbH

  • US 41222910 P 20101110
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  • WO 2007068354 A1 20070621 - MICROMET AG [DE], et al
  • WO 2011051307 A1 20110505 - MICROMET AG [DE], et al
  • WO 9954440 A1 19991028 - DOERKEN BERND [DE], et al
  • ALLEN SHIH ET AL.: "Role of Corticosteroids in Palliative Care", JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY, vol. 21, no. 4, 2007, pages 69 - 76, XP055443261
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  • GRUPP SA ET AL.: "Chimeric antigen receptor- modified T cells for acute lymphoid leukemia", N ENGL J MED, vol. 368, no. 16, 18 April 2013 (2013-04-18), pages 1509 - 1518, XP055169041
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  • LEE KJ ET AL.: "Clinical use of blinatumomab for B- cell acute lymphoblastic leukemia in adults", THER CLIN RISK MANAG, vol. 12, 25 August 2016 (2016-08-25), pages 1301 - 1310, XP055443269
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  • MATTHIAS KLINGER, CATALOGUE EXTRACT OF THE GERMAN NATIONAL LIBRARY ( DEUTSCHE NATIONALBIBLIOTHEK) REGARDING THE DISSERTATION, 2009
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  • VIARDOT A. ET AL.: "Treatment of patients with non-hodgkin lymphoma (NHL) with CD 19/ CD 3 bispecific antibody blinatumomab (MT103): Double-step dose increase to continuous infusion of 60 µg/m2/d is tolerable and highly effective", BLOOD, vol. 116, no. 21, 2010, pages 1186 - 1187, XP009161648
  • GOEBELER M. ET AL.: "CD 3/ CD 19 bispecific BITE@ antibody blinatumomab treatment of non-hodgkin lymphoma (NHL) patients: 60 µg/m2/d by continuous infusion is tolerable and results in durable responses", HAEMATOLOGICA - THE HEMATOLOGY JOURNAL, vol. 95, no. 2, June 2010 (2010-06-01), pages 230, XP002667641
  • BRANDL C ET AL.: "The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD 19/ CD 3-bispecific single-chain antibody construct", CANCER IMMUNOL IMMUNOTHER, vol. 56, no. 10, 20 February 2007 (2007-02-20), pages 1551 - 63, XP019539092
  • AMANN M.: "Anti-tumor activity, pharmacology and toxicology of EpCAM/ CD 3- bispecific single-chain antibodies", DISSERTATION, 2009, XP055443275
  • MARIA AMANN, INTERNET EXTRACT OF THE DISSERTATION/PUBLICATION SERVER OF THE UNIVERSITY OF MUNICH REGARDING THE DISSERTATION, 2009
  • BURGES A ET AL.: "Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti- CD 3 antibody: a phase I/II study", CLIN CANCER RES, vol. 13, no. 13, 1 July 2007 (2007-07-01), pages 3899 - 905, XP055167636
  • STROHLEIN MA ET AL.: "Induction of anti- tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis", J EXP CLIN CANCER RES, vol. 28, 14 February 2009 (2009-02-14), pages 1 - 10, XP021052973
  • SUÁREZ JI: "Treatment of acute brain edema", REV NEUROL, vol. 32, no. 3, 1 February 2001 (2001-02-01), pages 275 - 81, XP055443280
  • RUDERMAN NB ET AL.: "USE OF GLUCOCORTICOIDS IN THE PALLIATIVE TREATMENT OF METASTATIC BRAIN TUMORS", CANCER, vol. 18, March 1965 (1965-03-01), pages 298 - 306, XP055443292
  • WRIGHT AD ET AL.: "Birmingham Medical Research Expeditionary Society . Medicine at high altitude", CLIN MED (LOND, vol. 6, no. 6, November 2006 (2006-11-01), pages 604 - 608, XP055443294
  • HOFFMANN P ET AL.: "Serial killing of tumor cells by cytotoxic T cells redirected with a CD 19-/ CD 3- bispecific single-chain antibody construct", INT J CANCER, vol. 115, no. 1, 20 May 2005 (2005-05-20), pages 98 - 104, XP002335808

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2012062596 A1 20120518; AU 2011328393 A1 20130523; AU 2011328393 B2 20170105; AU 2017202079 A1 20170420; AU 2017202079 B2 20171130; AU 2018200915 A1 20180301; AU 2018200915 B2 20190919; CA 2816668 A1 20120518; CA 2816668 C 20210323; CL 2013001287 A1 20140221; CN 103533943 A 20140122; CN 103533943 B 20180213; CN 108403702 A 20180817; CR 20130278 A 20130920; CY 1118894 T1 20180110; DK 2637670 T3 20170619; DK 2637670 T4 20240325; EA 026075 B1 20170228; EA 201390621 A1 20140530; EP 2637670 A1 20130918; EP 2637670 B1 20170308; EP 2637670 B2 20240313; EP 3228315 A1 20171011; EP 3228315 B1 20201125; EP 3831386 A1 20210609; ES 2627538 T3 20170728; ES 2842937 T3 20210715; FI 2637670 T4 20240319; HR P20170814 T1 20170811; HR P20170814 T4 20240510; HU E032782 T2 20171030; IL 226268 A0 20130731; IL 226268 B 20180228; IL 257164 A 20180329; IL 257164 B 20200130; JP 2014504272 A 20140220; JP 2016193932 A 20161117; JP 6023717 B2 20161109; JP 6189491 B2 20170830; KR 101891845 B1 20180824; KR 20140008313 A 20140121; LT 2637670 T 20170525; MA 34726 B1 20131203; ME 02722 B 20171020; MY 173177 A 20200102; NZ 610034 A 20150529; PL 2637670 T3 20170831; PL 2637670 T5 20240610; PT 2637670 T 20170518; RS 55995 B1 20170929; RS 55995 B2 20240430; SG 10201508789T A 20151127; SG 190174 A1 20130731; SI 2637670 T1 20170630; SI 2637670 T2 20240628; TN 2013000250 A1 20141110; UA 113397 C2 20170125; US 10130638 B2 20181120; US 11633408 B2 20230425; US 2013287774 A1 20131031; US 2019142846 A1 20190516

DOCDB simple family (application)

EP 2011068862 W 20111027; AU 2011328393 A 20111027; AU 2017202079 A 20170329; AU 2018200915 A 20180207; CA 2816668 A 20111027; CL 2013001287 A 20130509; CN 201180064622 A 20111027; CN 201810044039 A 20111027; CR 20130278 A 20130610; CY 171100491 T 20170508; DK 11788077 T 20111027; EA 201390621 A 20111027; EP 11788077 A 20111027; EP 17159560 A 20111027; EP 20209362 A 20111027; ES 11788077 T 20111027; ES 17159560 T 20111027; FI 11788077 T 20111027; HR P20170814 T 20111027; HU E11788077 A 20111027; IL 22626813 A 20130509; IL 25716418 A 20180125; JP 2013538125 A 20111027; JP 2016133918 A 20160706; KR 20137014669 A 20111027; LT 11788077 T 20111027; MA 35999 A 20130610; ME P10417 A 20111027; MY PI2013001611 A 20111027; NZ 61003411 A 20111027; PL 11788077 T 20111027; PT 11788077 T 20111027; RS P20170458 A 20111027; SG 10201508789T A 20111027; SG 2013034731 A 20111027; SI 201131196 T 20111027; TN 2013000250 A 20130610; UA A201307130 A 20111027; US 201113884497 A 20111027; US 201816157985 A 20181011