EP 2640359 A4 20151104 - NOVEL COMPOSITIONS AND USES OF ANTI-HYPERTENSION AGENTS FOR CANCER THERAPY
Title (en)
NOVEL COMPOSITIONS AND USES OF ANTI-HYPERTENSION AGENTS FOR CANCER THERAPY
Title (de)
NEUE ZUSAMMENSETZUNGEN UND VERWENDUNGEN BLUTDRUCKSENKENDER MITTEL ZUR KREBSTHERAPIE
Title (fr)
NOUVELLES COMPOSITIONS ET UTILISATIONS D'AGENTS HYPOTENSEURS DANS LE TRAITEMENT DU CANCER
Publication
Application
Priority
- US 41519210 P 20101118
- US 201161438240 P 20110131
- US 2011061510 W 20111118
Abstract (en)
[origin: WO2012068531A2] Methods and compositions for improving the delivery and/or efficacy of cancer therapeutics are disclosed. Methods and compositions for treating or preventing a cancer (e.g., a solid tumor such as a desmoplastic tumor) by administering to a subject an antihypertensive agent, as a single agent or combination with a cancer therapeutic agent (for example, a therapeutic agent ranging in size from a large nanotherapeutic to a low molecular weight chemotherapeutics and/or oxygen radical) are disclosed.
IPC 8 full level
A61K 45/06 (2006.01); A61K 9/14 (2006.01); A61K 39/395 (2006.01)
CPC (source: EP)
A61K 39/395 (2013.01); A61K 45/06 (2013.01); A61P 9/00 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 13/12 (2017.12); A61P 17/00 (2017.12); A61P 19/02 (2017.12); A61P 21/00 (2017.12); A61P 35/00 (2017.12); A61P 35/04 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); A61K 9/127 (2013.01); A61K 9/1273 (2013.01)
Citation (search report)
- [I] US 6719977 B1 20040413 - SEED BRIAN [US], et al
- [X] NOGUCHI RYUICHI ET AL: "Synergistic inhibitory effect of gemcitabine and angiotensin type-1 receptor blocker, losartan, on murine pancreatic tumor growth via anti-angiogenic activities", ONCOLOGY REPORTS, vol. 22, no. 2, August 2009 (2009-08-01), pages 355 - 360, XP002744523, ISSN: 1021-335X
- [X] RHODES DANIEL R ET AL: "AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 106, no. 25, 23 June 2009 (2009-06-23), pages 10284 - 10289, XP002592235, ISSN: 0027-8424, [retrieved on 20090601], DOI: 10.1073/PNAS.0900351106
- [I] JAIN RAKESH K ET AL: "Delivering nanomedicine to solid tumors.", NATURE REVIEWS. CLINICAL ONCOLOGY NOV 2010, vol. 7, no. 11, 14 September 2010 (2010-09-14), pages 653 - 664, XP002744524, ISSN: 1759-4782
- [XP] B. DIOP-FRIMPONG ET AL: "Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 7, 31 January 2011 (2011-01-31), pages 2909 - 2914, XP055176833, ISSN: 0027-8424, DOI: 10.1073/pnas.1018892108
- See references of WO 2012068531A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012068531 A2 20120524; WO 2012068531 A3 20131128; AU 2011329638 A1 20130530; AU 2011329638 B2 20161013; AU 2011329638 C1 20170427; CA 2817250 A1 20120524; CN 103561726 A 20140205; EP 2640359 A2 20130925; EP 2640359 A4 20151104; JP 2014505666 A 20140306; JP 2017101056 A 20170608; RU 2013127625 A 20141227; RU 2018102375 A 20190221
DOCDB simple family (application)
US 2011061510 W 20111118; AU 2011329638 A 20111118; CA 2817250 A 20111118; CN 201180065389 A 20111118; EP 11841427 A 20111118; JP 2013540082 A 20111118; JP 2017019388 A 20170206; RU 2013127625 A 20111118; RU 2018102375 A 20111118