EP 2640737 B1 20180829 - DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION
Title (en)
DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION
Title (de)
DIPEPTIDANALOGA ZUR BEHANDLUNG VON STÖRUNGEN IM ZUSAMMENHANG MIT AMYLOID-FIBRILLENBILDUNG
Title (fr)
ANALOGUES DIPEPTIDIQUES POUR LE TRAITEMENT D'ÉTATS PATHOLOGIQUES ASSOCIÉ À LA FORMATION DE FIBRILLES AMYLOÏDES
Publication
Application
Priority
- US 41348810 P 20101115
- EP 10191253 A 20101115
- IL 2011050010 W 20111115
- EP 11794245 A 20111115
Abstract (en)
[origin: WO2012066549A1] Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The didpeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the didpetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
IPC 8 full level
C07K 5/078 (2006.01); A61P 25/28 (2006.01)
CPC (source: EP KR US)
A61K 38/05 (2013.01 - KR); A61P 3/10 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/06 (2017.12 - EP); C07K 5/06 (2013.01 - KR); C07K 5/06156 (2013.01 - EP US); A61K 38/00 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012066549 A1 20120524; AR 083885 A1 20130327; AU 2011330768 A1 20130530; BR 112013012033 A2 20160809; CA 2817830 A1 20120524; CN 103298826 A 20130911; EP 2640737 A1 20130925; EP 2640737 B1 20180829; EP 3431489 A1 20190123; EP 3431489 B1 20201223; IL 226360 A0 20130731; IL 226360 A 20171031; JP 2013544251 A 20131212; JP 5911503 B2 20160427; KR 20140014081 A 20140205; MX 2013005413 A 20140227; RU 2013126706 A 20141227; TW 201225972 A 20120701; US 2013225512 A1 20130829; US 2015322110 A1 20151112; US 9096645 B2 20150804; US 9630989 B2 20170425
DOCDB simple family (application)
IL 2011050010 W 20111115; AR P110104266 A 20111115; AU 2011330768 A 20111115; BR 112013012033 A 20111115; CA 2817830 A 20111115; CN 201180055035 A 20111115; EP 11794245 A 20111115; EP 18190280 A 20111115; IL 22636013 A 20130513; JP 2013539398 A 20111115; KR 20137014451 A 20111115; MX 2013005413 A 20111115; RU 2013126706 A 20111115; TW 100141597 A 20111115; US 201113884989 A 20111115; US 201514805490 A 20150722