Global Patent Index - EP 2643281 A4

EP 2643281 A4 20140604 - PREPARATION OF ISOMERICALLY PURE SUBSTITUTED CYCLOHEXANOLS

Title (en)

PREPARATION OF ISOMERICALLY PURE SUBSTITUTED CYCLOHEXANOLS

Title (de)

HERSTELLUNG ISOMERENREINER SUBSTITUIERTER CYCLOHEXANOLE

Title (fr)

PRÉPARATION DE CYCLOHEXANOLS SUBSTITUÉS ISOMÉRIQUEMENT PURS

Publication

EP 2643281 A4 20140604 (EN)

Application

EP 11843794 A 20111121

Priority

  • EP 10192721 A 20101126
  • IB 2011055199 W 20111121
  • EP 11843794 A 20111121

Abstract (en)

[origin: WO2012069974A1] Disclosed is a method for preparing isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols, which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated from the unreacted substituted cyclohexanol cis isomer.

IPC 8 full level

C12P 41/00 (2006.01); C07C 35/08 (2006.01); C12N 11/14 (2006.01); C12P 7/02 (2006.01)

CPC (source: EP)

C12N 11/14 (2013.01); C12P 7/02 (2013.01); C12P 41/004 (2013.01); C12Y 301/01003 (2013.01)

Citation (search report)

  • [A] WO 2005073215 A1 20050811 - BASF AG [DE], et al
  • [A] EP 2248906 A1 20101110 - AJINOMOTO KK [JP]
  • [I] US 2010086983 A1 20100408 - GELLETT WAYNE L [US], et al
  • [I] US 4665028 A 19870512 - AMOTZ SHMUEL [DK]
  • [A] BREUER ET AL: "Industrial methods for the production of optically active intermediates", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 43, 2004, pages 788 - 824, XP002339848
  • [A] STINSON: "Chiral Drugs", CHEMICAL & ENGINEERING NEWS, vol. 78, 2000, pages 1 - 10, XP002723173, Retrieved from the Internet <URL:http://www.technology-catalysts.com/pdf/TCI-CENews-1000.pdf> [retrieved on 20140409]
  • [A] XU ET AL: "Template-based modeling of a psychrophilic lipase: Conformational changes, novel structural features and its application in predicting the enantioselectivity of lipase catalyzed transesterification of secondary alcohols", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1804, 7 September 2010 (2010-09-07), pages 2183 - 2190, XP002723491
  • [I] COSTA-SILVA ET AL: "Partial purification and drying by spray dryer of extracellular lipases from the endophytic fungus Cercospora kikuchii", JOURNAL OF BIOTECHNOLOGY / SPECIAL ABSTRACTS, vol. 150S, pages S377, XP027489946
  • [I] YAMAMOTO ET AL: "Drying of enzymes: Enzyme retention during drying of a single droplet", CHEMICAL ENGINEERING SCIENCE, vol. 47, 1992, pages 177 - 183, XP002723492

Citation (examination)

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2012069974 A1 20120531; CN 103221370 A 20130724; CN 103221370 B 20150211; EP 2643281 A1 20131002; EP 2643281 A4 20140604; JP 2014500020 A 20140109

DOCDB simple family (application)

IB 2011055199 W 20111121; CN 201180056293 A 20111121; EP 11843794 A 20111121; JP 2013540467 A 20111121