Global Patent Index - EP 2651964 A4

EP 2651964 A4 20141015 - CROOS-LINKED PEPTIDES AND PROTEINS, METHODS OF MAKING SAME, AND USES THEREOF

Title (en)

CROOS-LINKED PEPTIDES AND PROTEINS, METHODS OF MAKING SAME, AND USES THEREOF

Title (de)

VERNETZTE PEPTIDE UND PROTEINE, VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNGEN DAVON

Title (fr)

PEPTIDES ET PROTÉINES RÉTICULÉS, LEURS PROCÉDÉS DE FABRICATION ET LEURS UTILISATIONS

Publication

EP 2651964 A4 20141015 (EN)

Application

EP 11848378 A 20111215

Priority

  • US 45956910 P 20101215
  • US 2011065282 W 20111215

Abstract (en)

[origin: WO2012083078A2] Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

IPC 8 full level

C07K 7/50 (2006.01); A61K 38/08 (2006.01); A61K 38/12 (2006.01); C07K 7/06 (2006.01)

CPC (source: EP US)

C07K 1/1077 (2013.01 - EP US); C07K 7/08 (2013.01 - EP US); C07K 7/56 (2013.01 - US); C07K 14/4747 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C07K 2319/95 (2013.01 - EP US)

Citation (search report)

  • [I] J. R. KUMITA ET AL: "Photo-control of helix content in a short peptide", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 97, no. 8, 11 April 2000 (2000-04-11), pages 3803 - 3808, XP055138290, ISSN: 0027-8424, DOI: 10.1073/pnas.97.8.3803
  • [I] FUZHONG ZHANG ET AL: "Stabilization of Folded Peptide and Protein Structures via Distance Matching with a Long, Rigid Cross-Linker", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, no. 46, 26 October 2007 (2007-10-26), pages 14154 - 14155, XP055137868, ISSN: 0002-7863, DOI: 10.1021/ja075829t
  • [XP] AVINASH MUPPIDI ET AL: "Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 21, no. 24, 4 October 2011 (2011-10-04), pages 7412 - 7415, XP028113897, ISSN: 0960-894X, [retrieved on 20111012], DOI: 10.1016/J.BMCL.2011.10.009
  • [XP] AVINASH MUPPIDI ET AL: "Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx", CHEMICAL COMMUNICATIONS, vol. 47, no. 33, 1 January 2011 (2011-01-01), pages 9396, XP055137829, ISSN: 1359-7345, DOI: 10.1039/c1cc13320a
  • See also references of WO 2012083078A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2012083078 A2 20120621; WO 2012083078 A3 20120816; EP 2651964 A2 20131023; EP 2651964 A4 20141015; EP 2651964 B1 20180228; US 2014057857 A1 20140227; US 9029332 B2 20150512

DOCDB simple family (application)

US 2011065282 W 20111215; EP 11848378 A 20111215; US 201113994296 A 20111215