EP 2658579 A4 20150722 - IN VIVO POLYNUCLEOTIDE DELIVERY CONJUGATES HAVING ENZYME SENSITIVE LINKAGES
Title (en)
IN VIVO POLYNUCLEOTIDE DELIVERY CONJUGATES HAVING ENZYME SENSITIVE LINKAGES
Title (de)
KONJUGATE ZUR IN-VIVO-ABGABE VON POLYNUKLEOTIDEN MIT ENZYMEMPFINDLICHEN BINDUNGEN
Title (fr)
CONJUGUÉS D'ADMINISTRATION DE POLYNUCLÉOTIDE IN VIVO AYANT DES LIAISONS SENSIBLES À DES ENZYMES
Publication
Application
Priority
- US 201113336028 A 20111223
- US 201061427936 P 20101229
- US 2011067588 W 20111228
Abstract (en)
[origin: WO2012092373A2] The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active poiyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalentiy linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
IPC 8 full level
A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07C 69/96 (2006.01); C08G 63/91 (2006.01)
CPC (source: EP KR RU)
A61K 47/58 (2017.07 - EP); A61K 47/60 (2017.07 - EP); A61K 48/00 (2013.01 - KR); A61P 1/16 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07C 69/96 (2013.01 - KR); C07C 233/05 (2013.01 - KR); C07K 5/06034 (2013.01 - EP); C07K 5/06078 (2013.01 - EP); C07K 5/06104 (2013.01 - EP); C07K 5/06113 (2013.01 - EP); C08G 63/91 (2013.01 - KR); C12N 15/87 (2013.01 - EP); C07K 5/06034 (2013.01 - RU); C07K 5/06078 (2013.01 - RU); C12N 15/111 (2013.01 - EP); C12N 2310/14 (2013.01 - EP); C12N 2310/3513 (2013.01 - EP); C12N 2320/32 (2013.01 - EP); C12N 2800/95 (2013.01 - EP); C12N 2810/10 (2013.01 - EP)
Citation (search report)
- [E] WO 2012083185 A2 20120621 - ARROWHEAD RES CORPORATIONS [US], et al
- [X] WO 02083180 A1 20021024 - DE GROOT FRANCISCUS MARINUS HE [NL], et al
- [X] US 2008293800 A1 20081127 - GANGWAR SANJEEV [US], et al
- [X] US 6180095 B1 20010130 - GREENWALD RICHARD B [US], et al
- [X] US 2007104719 A1 20070510 - CARTER PAUL J [US], et al
- [XYI] WO 2009141240 A1 20091126 - SIGMA TAU IND FARMACEUTI [IT], et al
- [Y] US 2003166601 A1 20030904 - WOODLE MARTIN C [US], et al
- [XY] DUBOWCHIK G M ET AL: "Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: Model studies of enzymatic drug release and antigen-specific in vitro anticancer activity", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 13, no. 4, 1 January 2002 (2002-01-01), pages 855 - 869, XP002978657, ISSN: 1043-1802, DOI: 10.1021/BC025536J
- See references of WO 2012092373A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012092373 A2 20120705; WO 2012092373 A3 20131024; AU 2011352204 A1 20130502; AU 2011352204 B2 20150521; BR 112013014115 A2 20190924; CA 2816041 A1 20120705; CA 2816041 C 20190108; CL 2013001876 A1 20140411; CL 2015003580 A1 20160715; CN 103491982 A 20140101; CN 103491982 B 20170912; EP 2658579 A2 20131106; EP 2658579 A4 20150722; JP 2014505685 A 20140306; JP 5941926 B2 20160629; KR 20130136494 A 20131212; MX 2013007316 A 20130729; MX 341118 B 20160809; MX 347298 B 20170421; NZ 611656 A 20141031; PE 20140198 A1 20140221; RU 2013117286 A 20150310; RU 2619453 C2 20170516; SG 189942 A1 20130628; ZA 201302896 B 20140725
DOCDB simple family (application)
US 2011067588 W 20111228; AU 2011352204 A 20111228; BR 112013014115 A 20111228; CA 2816041 A 20111228; CL 2013001876 A 20130625; CL 2015003580 A 20151210; CN 201180061179 A 20111228; EP 11853858 A 20111228; JP 2013547648 A 20111228; KR 20137017195 A 20111228; MX 2013007316 A 20111228; MX 2016006733 A 20111228; NZ 61165611 A 20111228; PE 2013001496 A 20111228; RU 2013117286 A 20111228; SG 2013029830 A 20111228; ZA 201302896 A 20130422