EP 2665731 A1 20131127 - FUSED AMINODIHYDROTHIAZINE DERIVATIVES
Title (en)
FUSED AMINODIHYDROTHIAZINE DERIVATIVES
Title (de)
KONDENSIERTE AMINODIHYDROTHIAZIN-DERIVATE
Title (fr)
DÉRIVÉS FUSIONNÉS D'AMINODIHYDROTHIAZINE
Publication
Application
Priority
- GB 201101139 A 20110121
- IB 2012000082 W 20120119
Abstract (en)
[origin: WO2012098461A1] The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an ?ß production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by ?ß and typified by Alzheimer-type dementia.
IPC 8 full level
A61P 25/28 (2006.01); C07D 513/04 (2006.01)
CPC (source: EP KR US)
A61K 31/542 (2013.01 - EP KR US); A61K 45/06 (2013.01 - EP US); A61P 3/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 513/04 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2012098461A1
Citation (examination)
WERMUTH C G: "MOLECULAR VARIATIONS BASED ON ISOSTERIC REPLACEMENTS", PRACTICE OF MEDICINAL CHEMISTRY, XX, XX, 1 January 1996 (1996-01-01), pages 203 - 237, XP002190259
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012098461 A1 20120726; WO 2012098461 A8 20130815; AU 2012208348 A1 20130801; BR 112013018601 A2 20190924; CA 2823675 A1 20120726; CN 103459401 A 20131218; EP 2665731 A1 20131127; GB 201101139 D0 20110309; IL 227252 A0 20130930; JP 2014506564 A 20140317; KR 20140020867 A 20140219; MX 2013008255 A 20131206; RU 2013138733 A 20150227; US 2014179690 A1 20140626; US 9175013 B2 20151103
DOCDB simple family (application)
IB 2012000082 W 20120119; AU 2012208348 A 20120119; BR 112013018601 A 20120119; CA 2823675 A 20120119; CN 201280006044 A 20120119; EP 12703573 A 20120119; GB 201101139 A 20110121; IL 22725213 A 20130627; JP 2013549905 A 20120119; KR 20137021750 A 20120119; MX 2013008255 A 20120119; RU 2013138733 A 20120119; US 201213979961 A 20120119