EP 2675806 A1 20131225 - 6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS
Title (en)
6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS
Title (de)
6-CYCLOALKYL-PYRAZOLOPYRIMIDINONE ZUR BEHANDLUNG VON STÖRUNGEN DES ZENTRALEN NERVENSYSTEMS
Title (fr)
6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES POUR LE TRAITEMENT DE TROUBLES DU SYSTÈME NERVEUX CENTRAL
Publication
Application
Priority
- EP 11154572 A 20110215
- EP 11154858 A 20110217
- EP 2012052379 W 20120213
- EP 12703130 A 20120213
Abstract (en)
[origin: WO2012110441A1] The invention relates to novel pyrazolopyrimidinones according to formula (I), wherein X is CRe or unsubstituted N, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, Ra, Rb, Rc, Rd, Re are either H or optional substituents, m= 1 or 2 and n is 0, 1 or 2. The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 25/00 (2006.01)
CPC (source: EP US)
A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/28 (2017.12 - EP); C07D 487/04 (2013.01 - EP US); C07D 519/00 (2013.01 - EP US)
Citation (search report)
See references of WO 2012110441A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2012110441 A1 20120823; AR 085226 A1 20130918; EP 2675806 A1 20131225; EP 2675806 B1 20150805; JP 2014505713 A 20140306; JP 5901659 B2 20160413; US 2013040955 A1 20130214; US 8809345 B2 20140819; UY 33910 A 20120831
DOCDB simple family (application)
EP 2012052379 W 20120213; AR P120100483 A 20120214; EP 12703130 A 20120213; JP 2013553887 A 20120213; US 201213369596 A 20120209; UY 33910 A 20120215