Global Patent Index - EP 2675808 A4

EP 2675808 A4 20140709 - PROCESS FOR PEMETREXED DISODIUM

Title (en)

PROCESS FOR PEMETREXED DISODIUM

Title (de)

VERFAHREN FÜR PEMETREXED-DINATRIUM

Title (fr)

PROCÉDÉ D'OBTENTION DE PEMETREXED DISODIQUE

Publication

EP 2675808 A4 20140709 (EN)

Application

EP 12747282 A 20120214

Priority

  • IN 434CH2011 A 20110215
  • IN 2012000103 W 20120214

Abstract (en)

[origin: WO2012111027A2] The present invention provides a process for the preparation of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid dimethyl ester or salts thereof. The present invention also provides a process for the preparation of pemetrexed disodium substantially free of enatiomeric impurity.

IPC 8 full level

C07D 487/04 (2006.01)

CPC (source: EP)

C07D 487/04 (2013.01)

Citation (search report)

  • [XP] WO 2011019986 A2 20110217 - REDDYS LAB LTD DR [IN], et al
  • [A] WO 9916742 A1 19990408 - LILLY CO ELI [US], et al
  • [XI] BARNETT C J ET AL: "A PRACTICAL SYNTHESIS OF MULTITARGETED ANTIFOLATE LY231514", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, CAMBRIDGE, GB, vol. 3, no. 3, 1 January 1999 (1999-01-01), pages 184 - 188, XP000982091, DOI: 10.1021/OP9802172
  • [X] EDWARD C. TAYLOR ET AL: "A New and Efficient Synthesis of Pyrrolo 2,3- d |pyrimidine Anticancer Agents: Alimta (LY231514, MTA), Homo-Alimta, TNP-351, and Some Aryl 5-Substituted Pyrrolo 2,3- d |pyrimidines", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 26, 1 December 2003 (2003-12-01), pages 9938 - 9947, XP055002811, ISSN: 0022-3263, DOI: 10.1021/jo030248h
  • [X] DOUGLAS P KJELL ET AL: "Determination of the source of N-methyl impurity in the synthesis of pemetrexed disodium heptahydrate", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 6, 18 November 2005 (2005-11-18), pages 739 - 742, XP002634585, ISSN: 1083-6160, [retrieved on 20051006], DOI: 10.1021/OP0498013
  • See references of WO 2012111027A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2012111027 A2 20120823; WO 2012111027 A3 20121011; EP 2675808 A2 20131225; EP 2675808 A4 20140709

DOCDB simple family (application)

IN 2012000103 W 20120214; EP 12747282 A 20120214