EP 2685825 A1 20140122 - SUBSTITUTED IMADAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
Title (en)
SUBSTITUTED IMADAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
Title (de)
SUBSTITUIERTE IMADAZOPYRIMIDIN-5(6H)-ONE ALS ALLOSTERISCHE MODULATOREN VON MGLUR5-REZEPTOREN
Title (fr)
IMADAZAPYRINIDIN-5(6H)-ONES SUBSTITUÉES EN TANT QUE MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS MGLUR5
Publication
Application
Priority
- US 201161452921 P 20110315
- US 2012029085 W 20120314
Abstract (en)
[origin: WO2012125732A1] In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
IPC 8 full level
A61K 31/519 (2006.01); A61P 25/00 (2006.01)
CPC (source: EP)
A61P 3/04 (2017.12); A61P 3/10 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/06 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/18 (2017.12); A61P 25/20 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12); C07D 487/04 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2012125732 A1 20120920; WO 2012125732 A8 20131017; AU 2012229983 A1 20131003; CA 2830220 A1 20120920; EP 2685825 A1 20140122; EP 2685825 A4 20140910; JP 2014508172 A 20140403
DOCDB simple family (application)
US 2012029085 W 20120314; AU 2012229983 A 20120314; CA 2830220 A 20120314; EP 12757940 A 20120314; JP 2013558139 A 20120314