Global Patent Index - EP 2687854 A1

EP 2687854 A1 20140122 - Test kit for the quantitative determination of narcotic drugs

Title (en)

Test kit for the quantitative determination of narcotic drugs

Title (de)

Testkit für die quantitative Bestimmung von narkotischen Arzneimitteln

Title (fr)

Kit de test pour la détermination quantitative de médicaments narcotiques

Publication

EP 2687854 A1 20140122 (EN)

Application

EP 12177125 A 20120719

Priority

EP 12177125 A 20120719

Abstract (en)

A test kit for the quantitative determination of narcotic drugs comprising (A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, - wherein the isotopologue differs from vessel to vessel and - wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel; - wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and contain at least three stable isotopes selected from the group consisting of 13 C, 15 N and 18 O in the molecule with a degree of labeling of at least 95 mol-%; the use of the test kit and a method for quantitatively determining narcotic drugs.

IPC 8 full level

G01N 33/94 (2006.01)

CPC (source: EP US)

G01N 30/72 (2013.01 - US); G01N 33/94 (2013.01 - EP US); G01N 33/946 (2013.01 - US)

Citation (applicant)

  • JP 2008266149 A 20081106 - TOKYO GAS CHEMICALS CO LTD, et al
  • WO 2004056398 A1 20040708 - PHARMACIA ITALIA SPA [IT], et al
  • US 2007116643 A1 20070524 - TUNG ROGER [US]
  • US 2009068706 A1 20090312 - FREUDENSCHUSS MARTIN [AT], et al
  • WO 2011024156 A1 20110303 - BRAIN WATCH LTD [IL], et al
  • WO 2006091885 A2 20060831 - PHARMA NOVA LLC DR [US], et al
  • US 2010130723 A1 20100527 - LATHAM KEITH R [US]
  • EP 11175719 A 20110728
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  • R. S. HSI; L. S. STELZER: "Synthesis of Adinazolam multiply labeled with Carbon-13 and Deuterium", JOURNAL OF LABELLED COMPOUNDS IN RADIOPHARMACEUTICALS, vol. XXVII, no. 3, 1989, pages 287 - 295
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  • CHOTIMA POEAKNAPO: "Evaluation of the mass spectrometric fragmentation of codeine and morphine after 13C-isotope biosynthetic labeling", PHYTOCHEMISTRY, vol. 65, 2004, pages 1413 - 1420
  • SIMON BEUK ET AL.: "Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 401, 2011, pages 493 - 505, XP019922806, DOI: doi:10.1007/s00216-011-4931-5
  • FRONTIERS OF BEHAVIORAL NEUROSCIENCE, vol. 5, September 2011 (2011-09-01)

Citation (search report)

  • [AD] US 2009068706 A1 20090312 - FREUDENSCHUSS MARTIN [AT], et al
  • [AD] US 2009208413 A1 20090820 - REIS ALAN J [US], et al
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  • [Y] CEDER GUNNEL ET AL: "CONCENTRATIONS OF UNCONJUGATED MORPHINE, CODEINE AND 6-ACETYLMORPHINE IN URINE SPECIMENS FROM SUSPECTED DRUGGED DRIVERS", JOURNAL OF FORENSIC SCIENCES, CALLAGHAN AND CO, CHICAGO, IL, US, vol. 47, no. 2, 1 January 2002 (2002-01-01), pages 366 - 368, XP009084540, ISSN: 0022-1198
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  • [Y] RAY H. LIU ET AL: "Peer Reviewed: Isotopically Labeled Analogues for Drug Quantitation", ANALYTICAL CHEMISTRY, vol. 74, no. 23, 1 December 2002 (2002-12-01), pages 618 A - 626 A, XP055042281, ISSN: 0003-2700, DOI: 10.1021/ac022161m
  • [A] WEI-TUN CHANG ET AL: "Mechanistic Studies on the Use of 2H- and 13C-Analogues as Internal Standards in Selected Ion Monitoring GC-MS Quantitative Determination-- Butalbitai Example", JOURNAL OF ANALYTICAL TOXICOLOGY, vol. 25, 1 January 2001 (2001-01-01), pages 659 - 669, XP055042282
  • [A] RODGER L. FOLTZ ET AL: "GC/MS ASSAYS FOR ABUSED DRUGS IN BODY FLUIDS", NIDA RES MONOGR., vol. 32, 1 January 1980 (1980-01-01), pages 1 - 214, XP055042287
  • [A] SINGH G ET AL: "A validated stable isotope dilution liquid chromatography tandem mass spectrometry assay for the trace analysis of cocaine and its major metabolites in plasma", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 71, no. 10, 15 May 1999 (1999-05-15), pages 2021 - 2027, XP009100102, ISSN: 0003-2700, DOI: 10.1021/AC981060E
  • [A] WANG S M ET AL: "Simultaneous determination of amphetamine and methamphetamine enantiomers in urine by simultaneous liquid-liquid extraction and diastereomeric derivatization followed by gas chromatographic-isotope dilution mass spectrometry", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 816, no. 1-2, 25 February 2005 (2005-02-25), pages 131 - 143, XP027626893, ISSN: 1570-0232, [retrieved on 20050225]

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 2687854 A1 20140122; AU 2013291925 A1 20150205; AU 2013291925 B2 20181129; CA 2878670 A1 20140123; CA 2878670 C 20201110; EP 2875362 A1 20150527; US 2015204893 A1 20150723; US 9347961 B2 20160524; WO 2014013063 A1 20140123

DOCDB simple family (application)

EP 12177125 A 20120719; AU 2013291925 A 20130719; CA 2878670 A 20130719; EP 13747805 A 20130719; EP 2013065323 W 20130719; US 201314414146 A 20130719